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X Inactivation Hypothesis

X Inactivation Hypothesis . - proposed by Mary Lyons - British geneticist. Barr Bodies. When one of the X chromosomes inactivates, it condenses into a black spot outside of the nucleus This inactivation occurs in a random pattern. XY – no barr bodies XXY – 1 barr body. XX – 1 barr body

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X Inactivation Hypothesis

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  1. X Inactivation Hypothesis - proposed by Mary Lyons - British geneticist

  2. Barr Bodies • When one of the X chromosomes inactivates, it condenses into a black spot outside of the nucleus • This inactivation occurs in a random pattern

  3. XY – no barr bodies XXY – 1 barr body XX – 1 barr body XXX – 2 barr bodies How many Barr Bodies?

  4. Practical Example • Calico Cats • They carry 2 different alleles for coat color • Random X inactivation during embryonic development causes the patchwork colored coat in some female cats

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