1 / 7

Project Annotated Bibliography is due Thursday, September 18

Project Annotated Bibliography is due Thursday, September 18. https:// bio3170bioinformatics.wordpress.com/category/project/annotated-bibliography/. Gene alignments: a ntibiotic resistance. Protein alignments: function of CFTR protein.

erelah
Download Presentation

Project Annotated Bibliography is due Thursday, September 18

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Project Annotated Bibliography is due Thursday, September 18 https://bio3170bioinformatics.wordpress.com/category/project/annotated-bibliography/

  2. Gene alignments: antibiotic resistance Protein alignments: function of CFTR protein Exploring bioinformatics: Nova Scotia Niemann-Pick Disease Manipulating genetic data: genetic disease Sequence assembly: human genome Bioinformatics and Computational Biology (BCB) Agent-based models: foraging ants Gene prediction: prokaryotic gene discovery Mathematical models: infectious disease Microarrays: zinc-induced gene expression Structure prediction: drug design

  3. The learning objectives for module 3 relate to aligning proteins • Understand the differences between DNA and protein alignments • State the value of being able to score similarity as well as identify in protein alignments • Investigate how protein comparisons yield clues to the function of an unknown protein Protein alignments: function of CFTR protein

  4. Suppose a mutation changes a codon in a gene from GUA to GAA. What is the corresponding amino-acid change? http://en.wikipedia.org/wiki/DNA_codon_table

  5. What are two ways in which this small change in DNA can produce a drastic change in the function of the protein encoded by this gene? DNA binding protein Interaction with other molecules: A protein can only interact with other molecules if it has the correct amino acids with the correct side chains to bind those molecules. Leucine zipper (red residues) (positively charged) Protein folding: Amino acid sequence determines how a protein can fold; the ability of a protein to interact with other molecules is dependent on folding. DNA (negatively charged) http://en.wikipedia.org/wiki/Leucine_zipper

  6. Even though the GUA to GAA mutation changes only a single nucleotide, it is rarely observed when comparing actual genes from different organisms. Why isn't it more common? Protein alignment scores similar and identical amino acids “Good” DNA alignment shows little similarity at amino acid level

  7. Suppose a gene's coding sequence begins with ATGCTCCGGCAAAGG.... A gene in another organism begins with the sequence ATGTTAAGAAACCGT..., so there does not seem to be much sequence similarity. Would our conclusion be different if this were a protein alignment? (Hint: Translate the two sequences before answering the question.) ATG CTC CGG CAA AGG M L R Q R ATG CTCCGGCAAAGG ATG TTAAGAAACCGT M L R N R ATG TTA AGA AAC CGT http://en.wikipedia.org/wiki/Genetic_code

More Related