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Histology Laboratories Molecules to Systems 2003 Compiled by James D. Jamieson, MD/PhD

Histology Laboratories Molecules to Systems 2003 Compiled by James D. Jamieson, MD/PhD Thomas L. Lentz, MD. No part of this image collection may be distributed outside of the Yale University Intranet. Acknowledgements. Sources of Micrographs, Diagrams and Figures.

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Histology Laboratories Molecules to Systems 2003 Compiled by James D. Jamieson, MD/PhD

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  1. Histology Laboratories Molecules to Systems 2003 Compiled by James D. Jamieson, MD/PhD Thomas L. Lentz, MD No part of this image collection may be distributed outside of the Yale University Intranet.

  2. Acknowledgements Sources of Micrographs, Diagrams and Figures Alberts, B. et al. Molecular Biology of the Cell. 4th Edition, Garland Science, New York, 2002. Gartner, L. P. and Hiatt, J. L. Color Atlas of Histology, Williams & Wilkins, Baltimore, 1994. Kerr, J. B. Atlas of Functional Histology. Mosby, London, 1999. Kessel, R. G. and Kardon, R. H. Tissues and Organs: a text-atlas of scanning electron microscopy. W. H. Freeman, San Francisco, 1979. Lentz, T. L. Cell Fine Structure. W. B. Saunders, Philadelphia, 1971. Lodish, H. et al. Molecular Cell Biology. W. H. Freeman, New York, 2000. Mizoguti, H. Color Slide Atlas of Histology. Nihon Shashin Shinbunsha, Tokyo. Young, B. and Heath, J. W. Wheater’s Functional Histology. Churchill Livingstone, Edinburgh, 2000. Micrographs taken by George Palade, Marilyn Farquhar, James D. Jamieson, Nicolai Simionescu, Maya Simionescu, David Castle, Thomas L. Lentz. Web Resources http://info.med.yale.edu/webpath/webpath.htm Cushing Library Educational Software/Cell Biology/Several Histology Resources

  3. Bone Laboratory

  4. Adult Bone

  5. Some Useful Terms Compact bone = cortical bone Trabecular bone = spongy = cancellous bone Osteoid: Bone matrix not yet calcified. Woven bone: immature bone with randomly arranged collagen fibers. Produced when osteoblasts rapidly produce osteoid as in fetal bone development; fracture repair (callus). Lamellar bone: regular parallel bands of collagen. Woven bone eventually remodeled into lamellar bone. The normal form of bone in adults.

  6. Trabecular bone Compact bone

  7. Volkmann’s canals Lamellar bone Haversian canals Cortical Bone

  8. Canaliculi Haversian canal Osteocytes Osteon: Lamellar Bone

  9. Osteocytes in Lacunae in Lamellar Bone

  10. Trabecular Bone

  11. Muscle Trabecular Bone: XS Long Bone

  12. Endosteum Periosteum Trabeculae Marrow Trabecular Bone

  13. Fibrous layer Osteoclasts Cellular layer Compact bone Periosteum

  14. Endosteum Bone Marrow

  15. Articular Surface of Long Bone Collagen layer Cartilage Bone Articular Surface of Long Bone

  16. Bone Formation

  17. Intramembranous Ossification (No cartilage model; bones of skull)

  18. Osteoblasts Osteoclasts Intramembranous Ossification: Fetal Skull

  19. Osteoblasts Osteoclasts Intramembranous Ossification: Fetal Skull

  20. Endochondral Ossification (Ribs, long bones, vertebrae; cartilage model)

  21. Endochondral Bone Formation

  22. Epiphysis (E) Epiphysis Diaphysis Epiphyseal growth plates (GP) Fetal Finger

  23. Epiphysis With Trabecular Bone E GP Metaphysis

  24. Articular cartilage E GP M D Growing Tibia

  25. Calcified cartilage GP Bone Osteoid Growing Tibia

  26. Resting Proliferation Maturation Hypertrophy Zone of calcifying cartilage Chondrocyte Growth Sequence

  27. Calcified cartilage Osteoblasts; osteoid Bone Development of Trabecular Bone

  28. Bone Remodeling Activation Resorption Formation Sequence

  29. Howship’s lacuna Osteoclasts

  30. Osteoid Osteocytes in new lamellar bone Osteoblasts (OB) Vessels in Resorption Canal

  31. OB Osteoid Resorption Canal XS

  32. Some pathology to think about.

  33. Mammary Carcinoma Metastases to Vertebra

  34. Callus at Fracture Site

  35. New Bone at Fracture Site

  36. Osteoporosis with Vertebral Collapse

  37. Osteogenic Sarcoma/Osteoid

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