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Prepared for the L aboratory for P roduct and P rocess D esign Created by Eric Lueshen

Prepared for the L aboratory for P roduct and P rocess D esign Created by Eric Lueshen Presented on January 8, 2010. Fall 2009 Semester Research. Fall 2009 Research Projects. Nanoparticle (NP) experiments project (90-100%?) NP synthesis & economic feasibility analysis (85-90%)

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Prepared for the L aboratory for P roduct and P rocess D esign Created by Eric Lueshen

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  1. Prepared for the Laboratory for Product and Process Design Created by Eric Lueshen Presented on January 8, 2010 Fall 2009 Semester Research

  2. Fall 2009 Research Projects Nanoparticle (NP) experiments project (90-100%?) NP synthesis & economic feasibility analysis (85-90%) New catheter design experiments & article with Dr. Alex (60%) Porous membrane catheter experiments & article with Nikhil and Dr. Alex (80%) TA duties for BioE 310 (100%) Drug delivery program Controlling the distribution of an injection using a suction catheter Applied for NSF GRFP

  3. Nanoparticle Experiments Fluorescently-labeled PLGA NPs LNK ChemSolutions Infused into gel and rat striatum; visualized Fluorescent carboxymethyl dextran superparamagnetic NPs Infused into gel and visualized Seeded 400 nm NP experiments Visualized the deformation of gel along the catheter shaft More work on perfecting these experiments is needed

  4. Injection site: Striatum Figure 1. Injection site: striatum

  5. NP Synthesis & Economic Feasibility Analysis aminoPVA coated MNPs best for drug delivery into the brain and for cellular uptake Two feasible synthesis methods are thermal decomposition and co-precipitation Chemicals, equipment, etc. needed were researched and price comparisons were made N2 Water ∞ Co-precipitant ∞ After 30 min T = 80C ∞ Figure 3. Co-precipitation Method Figure 2. Thermal Decomposition Method

  6. New Catheter Design Experiments & Article Catheter with an inner-wire experiments & analysis completed Article draft is in progress with Dr. Alex (d) Figure 4. Photographs of catheter with inner wire at 5.0 µL/min at (a) 0 min, (b) 50 min, (c) 100 min and (d) 200 min. (a) (b) (c)

  7. Porous Membrane Catheter Experiments & Article (g) Figure 5. Calibration pictures for 3rd article with different amount of 0.1% BPB dye: (a) 0.0 mL (b) 0.25 mL (c) 0.5 mL (d) 2.0 mL (e) 3.0 mL (f) 4.0 mL and (g) 5.0 mL. Figure 6. Porous membrane catheter experiment for 3rd article at 2.0 µL/min at: (a) 0 hour (b) 1 hour (c) 2 hours (d) 3 hours and (e) 4 hours. (a) (d) (b) (e) (c) (f) (d) (a) (b) (e) (c)

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