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Immunology

Immunology. E.Richter Department of Rheumatology University of Stellenbosch. Innate and adaptive immunity: cells. Innate and adaptive immunity. MHC class I and II. Complement system. Activation of innate immunity. PAMP’s and PRR. I nflammasomes. Jak Stat pathway. Cytokines.

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Immunology

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  1. Immunology E.Richter Department of Rheumatology University of Stellenbosch

  2. Innate and adaptive immunity: cells

  3. Innate and adaptive immunity

  4. MHC class I and II

  5. Complement system

  6. Activation of innate immunity

  7. PAMP’s and PRR

  8. Inflammasomes

  9. Jak Stat pathway

  10. Cytokines

  11. Important cytokines: TNF-alfa

  12. Interleukin-6

  13. Interleukin-6 and the liver

  14. Adaptive immunity: T cell development Positive selection: selection of T cells capable of interacting with MHC molecules. If does not bind to MHC  apoptosis. Develops into either CD4 or CD8 depending on if it binds MHC class I or II. Negative selection: presented with MHC bound to self Ag. If binds too strongly  apoptosis.

  15. Activation of T cell Requires both signals in order to activate. CD 28 expressed on all CD4 and 50% of CD8 CTLA-4 negative regulator of T cells. Only transiently expressed after T cell activation.

  16. T-helper cells: subsets

  17. Adaptive immunity: B cells development

  18. B cells: activation

  19. Immunoglobulin's

  20. Autoimmunity Black arrows=normal events in T cell development Red arrows = circumstances disrupting events autoimmunity

  21. Autoimmunity

  22. Autoimmunity: superantigen

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