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Neoplasia 10 Malignant Mesenchymal tumours SARCOMA

Neoplasia 10 Malignant Mesenchymal tumours SARCOMA. By Soheir Mahfouz. MESENCHYMAL Neoplasms. Mesenchymal Neoplasms Malignant SARCOMAS. GROSS FEATURES 1) Shape : Irregular 2) Surface : non capsulated rough 3) Cut section: mottled (hemorrhage & necrosis)

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Neoplasia 10 Malignant Mesenchymal tumours SARCOMA

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  1. Neoplasia 10 Malignant Mesenchymal tumours SARCOMA By Soheir Mahfouz

  2. MESENCHYMAL Neoplasms

  3. Mesenchymal Neoplasms Malignant SARCOMAS • GROSS FEATURES 1) Shape: Irregular 2)Surface:non capsulated rough 3) Cut section: mottled (hemorrhage & necrosis) 4) Colour: red- yellow & original colour 5) Consistency: fleshy

  4. Mesenchymal NeoplasmsMalignant Sarcomas • MICROSCOPIC FEATURES • Cells are arranged in sheets each cell separated by stroma specific to tissue • BV are confined to stroma and more numerous than carcinomas • Malignant criteria • According to degree of similarity to original: Well – Moderate –poorly differentiated (or Grades 1-3). undifferentiated tumours bear no resemblance at all: spindle /round cell or giant cell sarcomas

  5. BR Microscopic picture of malignancy • Pleomorphism • Hypercellularity • Hyperchromasia • High N/C ratio • Many Mitotic figures • Invasion

  6. Today’s lesson • SARCOMAS 45. Giant cell tumour (Osteoclastoma) 46. Fibrosarcoma 48. Osteosarcoma • PIGMENTED LESIONS 50. Melanocytic nevus 51. Melanoma

  7. 46

  8. MESENCHYMAL T. Fibrosarcoma • Definition: Malignant tumour of FT origin • Sites: Subcutaneous & submucous FT Intermuscular septae, fascia, ligaments,tendons Retroperitoneal tissue & periosteum FT stroma of organs

  9. 46 Fibrosarcoma Fibroma

  10. Poorly differentiated Fibrosarcoma /spindle cell sarcoma 46

  11. 48

  12. MESENCHYMAL T. osteosarcoma 48

  13. 48

  14. 45

  15. 45

  16. 50

  17. Tumour-like lesionsHamartoma Nevi 50

  18. 50

  19. 51

  20. 51

  21. 51

  22. RESOURCES 1-Pathology department image collection 2-Mahfouz image collection 3- WEBSITES Important web sites from which many images or text were taken. NB. Those not mentioned may be found on web searches: google , Yahoo & ask.com http://www.pathmax.com/ http://www-medlib.med.utah.edu/WebPath/LABS/LABMENU.html#2 http://www.med.uiuc.edu/PathAtlasf/titlePage.html http://www.medscape.com/pathologyhome http://www.gwumc.edu/dept/path/2F.HTM http://ampat.amu.edu.pl/czasopis/contents.htm http://www.urmc.rochester.edu/smd/pathres/long.html http://www.medscape.com/pathology/cme http://www.mic.ki.se/Diseases/C23.html http://dir.yahoo.com/Health/medicine/pathology/ http://www.iaphomepage.org/ http://search.msn.com/results.aspx?q=Pathology+lectures+on+line&FORM=QBRE2 http://dpalm.med.uth.tmc.edu/faculty/bios/hunter/pathlinks.htm http://www.pathmax.com/main.html http://www.pathguy.com

  23. RESOURCES http://www.emedicine.com/oncology/ http://www.thedoctorsdoctor.com/diseases/liposarcoma.htm#histo http://www.humpath.com/article.php3?id_article=3532 http://www.ec.upstate.edu/path/ http://peir.net/ http://medstat.med.utah.edu/WebPath/webpath.html ATLAS http://www.emedicine.com/asp/image_search.asp?query=actinomycosis&offset=12 http://erl.pathology.iupui.edu/C604/INDEX.HTM http://www.path.uiowa.edu/virtualslidebox/ http://www.mic.ki.se/MEDIMAGES.html#G02.403.776.600 http://www.palms.med.usyd.edu.au/pathology_museum/ http://www.med.uiuc.edu/PathAtlasf/titlePage.html http://images.google.com/imgres?imgurl=http://www.images.md/intermedia/imgagent/mediaget/getwatermarked/ACNCR01-09-55-001&imgrefurl=http://www.images.md/users/explore_chapter.asp%3FID%3DACNCR01-09-55%26colID%3DACNCR01-09%26coltitle%3DBreast%2BCancer&h=80&w=120&sz=11&tbnid=EZu7ubDWDdUUIM:&tbnh=55&tbnw=83&hl=en&start=67&prev=/images%3Fq%3DFine%2BNeedle%2BAspiration%2Bof%2BBreast%26start%3D60%26svnum%3D10%26hl%3Den%26lr%3D%26sa%3DN

  24. RESOURCES http://images.google.com/imgres?imgurl=http://www.hopkinsbreastcenter.org/pathology/benign/1j.jpg&imgrefurl=http://www.hopkinsbreastcenter.org/library/educational_information/benign.shtml&h=380&w=492&sz=289&tbnid=NTEcMCp3mRuZbM:&tbnh=98&tbnw=127&hl=en&start=1&prev=/images%3Fq%3DFine%2BNeedle%2BAspiration%2Bof%2BBreast%26svnum%3D10%26hl%3Den%26lr%3D http://images.google.com/imgres?imgurl=http://www.webpathology.com/slides/thumbnails/Testes_SexCord_GranulosaCellTumor2TN.jpg&imgrefurl=http://www.webpathology.com/case.cfm%3Fcase%3D38&h=76&w=101&sz=6&tbnid=yup1zvPUIS1u3M:&tbnh=58&tbnw=78&hl=en&start=21&prev=/images%3Fq%3Dgranulosa%2Bcell%2Btumour%2Bovary%26start%3D20%26svnum%3D10%26hl%3Den%26lr%3D%26sa%3DN http://screening.iarc.fr/index.php http://web.med.unsw.edu.au/pathology/Pathmus/pathmus.htm#InteractiveImages http://www.hopkinsbreastcenter.org/library/educational_information/benign.shtml http://eulep.anat.cam.ac.uk/Search_Pathbase/index.php?actiontype=search&mpath= http://www.diesis.com/fabrizio/atlas/ Dermatopath http://www.derm.ubc.ca/pathology/micrneurann.htm http://tray.dermatology.uiowa.edu/DPT/DPTutor.htm Reproductive http://images.google.com/imgres?imgurl=http://www.path.sunysb.edu/coursemat/reproimages/thumbs/4thumb.jpg&imgrefurl=http://www.path.sunysb.edu/coursemat/reproslides.htm&h=86&w=120&sz=5&tbnid=aVSQELIjiWfBAM:&tbnh=59&tbnw=83&hl=en&start=25&prev=/images%3Fq%3Dgranulosa%2Bcell%2Btumour%2Bovary%26start%3D20%26svnum%3D10%26hl%3Den%26lr%3D%26sa%3DN Respiratory http://iris.nyit.edu/~edoran/Course/Resp1lect01.htm#NORMAL%20ANATOMY%20LUNGS

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