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Exploring DNA Function and Epigenetics in an Interdisciplinary Investigation

Join an IDI chemistry Exploration of DNA and Epigenetics. Learn about DNA functions like replication, gene expression, and methylation. Understand how cells regulate genes for different fates and diseases. Engage in predicting molecular shapes and exploring DNA molecules' chemical aspects.

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Exploring DNA Function and Epigenetics in an Interdisciplinary Investigation

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  1. Epigenetics: Investigating the Structure & Function of Deoxyribonucleic Acid (DNA)

  2. Interdisciplinary Investigations (IDI) Chemistry 121 This Investigation: Day 1: Introduction DNA Function & Epigenetics Structure of DNA Day 2: Seminar on Scientific American Article Epigenetics

  3. Pre-Lab Discussion What did you find most interesting about each video?

  4. A. Functions of DNA DNA Replication: DNA must be accurately copied to allow for the production of new cells during growth, repair, and reproduction. Gene Expression: Specific regions of DNA, called genes, must convey information to allow cells to build the needed proteins through transcription and translation.

  5. Functions of DNA DNA Replication:

  6. DNA Replication: Let’s Watch http://www.youtube.com/v/4jtmOZaIvS0

  7. Functions of DNA Gene Expression

  8. Epigenetics and DNA Methylation: • Do all your cells have the same DNA? • Do all your cells use all their DNA? Why or why not?

  9. All Our Cells Work From Essentially the Same Genome/DNA Template. Thus cells must be able to regulate which genes they use.

  10. Epigenetics and DNA Methylation: • Differential gene expression allows different cell types to adopt different fates. • Mistakes in gene regulation are associated with a variety of diseases, especially cancer.

  11. Gene Regulation Plays an Important Role in Many Diseases

  12. DNA Methylation This reaction is enzyme-mediated. DNA methylation silences genes. Write down your ideas for the three questions in Part A!

  13. B. Predicting Shape and Interpreting Chemical Representations of Multi-Central Atom Molecules

  14. C. Parts of the DNA Molecule

  15. C:Parts of the DNA Molecule Sugar Nitrogenous Bases

  16. D. Linking Through Chemical Bonds

  17. The Phosphodiester Bond

  18. DNA Double Helix

  19. E. Focus on Cytosine Find your model of cytosine that you built earlier. Where does the methyl group go when methylation occurs? Add this to your model. methyl group

  20. E. Focus on Cytosine DNA methylation silences genes.

  21. Impacts of DNA Methylation How does methylation of DNA “silence” a gene? Why is this a significant event in terms of leading to disease?

  22. Impacts of DNA Methylation https://www.youtube.com/watch?v=2NVBsPfOtT8

  23. DNA Methylation: Let’s Watch https://www.youtube.com/watch?v=29doT6Hf2MI&list=PLU1BVhkEIXAHNboZCjPi2dovL1N9EazoJ

  24. Impacts of DNA Methylation

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