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Cancer Wellness Center May 13, 2010 Anne Leavell, MS, RD, LDN, CDE Department of Neurology, Northwestern Medical Facult

Supplements For Your Nervous System. Cancer Wellness Center May 13, 2010 Anne Leavell, MS, RD, LDN, CDE Department of Neurology, Northwestern Medical Faculty Foundation. Supplements. Disclaimer:

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Cancer Wellness Center May 13, 2010 Anne Leavell, MS, RD, LDN, CDE Department of Neurology, Northwestern Medical Facult

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  1. Supplements For Your Nervous System Cancer Wellness Center May 13, 2010 Anne Leavell, MS, RD, LDN, CDE Department of Neurology, Northwestern Medical Faculty Foundation

  2. Supplements Disclaimer: Dietary supplementation should NOT be initiated without the supervision of a qualified physician. Check with your doctor before you begin. Several of these supplements may have adverse effects

  3. Supplements • Vitamin E • Powerful antioxidant that reduces levels of free radicals and oxidative stress. • Protects against side effects: numbness, tingling, burning and pain • B Complex: B1(thiamine), B2(riboflavin), B3(niacin), B5(pantothenic acid), B6(pyridoxine), B7(biotin), B9(folic acid), B12(cobalamins) • B12 deficiency results in damage to protective covering of nerves • Decrease in pain (B1/B6/B12) • Folic acid (B9): maintenance of nerve cells

  4. Supplements • Acetyl-L-Carnitine • Neuroprotective properties • 2 small studies - limit chemotherapy induced neuropathy • More studies needed, effectiveness not established • Alpha lipoic acid • Benefit in diabetic neuropathy (less pain, burning and numbness) • Further studies needed for safety/efficacy of ALA in prevention/treatment of chemotherapy induced neuropathy

  5. Supplements • Glutamine • A neutral nonessential amino acid though to have neuroprotective effects (particularly with Paclitaxel) • More research needed to assess efficacy of glutamine • Glutathione • Tripeptide thought to prevent neurotoxicity • Efficacy seen in 50 advanced gastric cancer undergoing cisplatin-based chemotherapy

  6. Supplements • Magnesium/Calcium • Improvements in neurotoxicity following infusion • Caution: may cause diarrhea in large doses • Need more research to evaluate use as prevention/treatment of chemotherapy induced neuropathy • N-acetylcysteine (amino acid) • Powerful antioxidant • Animal studies have shown inhibition of diabetic neuropathy and protection against neuropathies caused by chemotherapy drugs

  7. Supplements • Omega-3 fatty acids: • High quantities in coldwater fish (salmon) and widely consumed for anti-inflammatory powers • Essential fatty acids and important component of cell membranes, myelin sheath that protects nerves • Studies show ability to reduce demyelination of nerves and neuropathic pain

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