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BIOL 2030 Human Anatomy & Physiology II. Why do we need vessels ?. At one point blood believed to be replenished as it was consumed by the tissues. Let’s calculate the cardiac output of a resting student… (70ml/beat) * (70 beats/min) = 4900 ml/min How much blood “used up” per day ?
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BIOL 2030 Human Anatomy & Physiology II Why do we need vessels? At one point blood believed to be replenished as it was consumed by the tissues. Let’s calculate the cardiac output of a resting student… (70ml/beat) * (70 beats/min) = 4900 ml/min How much blood “used up” per day? How many liters of water would you have to drink?
What are the similarities between vessels? 3 Main layers (or tunics) 1) _____________connective tissue 2) ____________smooth muscle and elastic fibers 3) ____________connective tissue, basement membrane and endothelium
What are the differences between vessels? Vessels classified by: 1) __________ ____________Arteries = A____Veins = __v____ 2) _________
Medium vein Elastic artery Muscular artery What are the differences between vessels? Vessels classified by: 3) ___________ 4) _________
What’s unique about capillaries? • The 3 tunics not present • _____________ continuous with _____________ • _______________________ • ___________
What are the differences between capillaries? • ___________________*no gaps in endothelium*found in muscles and nerves etc. • ____________________*big gaps in endothelium*found near endocrine glands (WHY?) • ___________________* “windows” in cell membranes *found in intestines, choroid processes, kidneys (WHY?) Which type most common?
How is capillary flow regulated? What function(s) do these sphincters accomplish?
What are the physics of flow? __________: Smooth flowing fluids in concenctric layers __________: Rough, irregular flow in multiple directions __________: A fluid’s Resistance to flow Flow, Pressure & resistance Poiseuille’s law Critical closing pressure
What is your blood pressure and how can you measure it? Determining blood pressure indirectly relies on:1) 2) 3)
What is your pulse and how can you measure it? Your pulse is a measure of the # of heart beats per minute Can be determined via: __________ = apical pulse ______________= temporal, facial, carotid, axillary, brachial, radial, femoral, popliteal, dorsalis pedis and posterior tibial __________ = carotid
Take 5!!! Predict the effect of each of the following conditions on blood flow:a) vasoconstriction of blood vessels in the skin in response to coldb) vasodilation of dermal vessels due to heatc) polycythemia vera (> hematocrit)!
What are the physics of phlow? Velocity and Area Pressure & Resistance 100 95 30 0 10 Pulse pressure
Take 5!!! Explain the consequences of worsening arteriosclerosis on a large aortic aneurysm.
How is blood flow to tissues regulated? Flow regulated by:1)______________Needs of organs/tissues met by demands.As metabolism > so does what?These cause relaxation of ________________ and ____________. __________________ Demand &_____________
What is mean arterial blood pressure? M.A.B.P. is proportional to __________ CO = _____________________ Venous return can influence _________________ End-systolic volume can decrease because of increased ________________ Difference between CO at rest and maximal CO is known as _________________
How is blood flow to tissues regulated? Flow regulated by:2)_______________ Most vessels (except capillaries) innervated sympathetically, & are associated with the ________ _________of the brain (pons/medulla oblongata). Consists of _________ and _________ regions Constant excitatory signals result in ________________
How is blood pressure regulated? Short term____________: What do they do? How do they respond? ____________:What do they do? How do they respond? ____________________________:When stimulated? What result? __________________: When medulla is metabolically stressed fires many action potentials…results in > vasomotor tone. Emergencies and short-lived
How is blood pressure regulated? Long termRenin-Angiotensin-Aldosterone Mechanism:series of enzymes that influence ____________________________ Vasopressin (ADH):both names imply function... Atrial natriuretic hormone:Name again describes origin and function Fluid shift:As b.p. ___ fluid moves from interstitial spaces back _________________ Stress-Relaxation response:Depending on stress level, __________________ contract and relax accordingly.
Where does blood go? 2 main categories of circulation: • Pulmonaryto and from lungs • Systemicto and from body Refer to pg. 718 and know the listed arteries!
Where does blood go? Refer to pg. 729 and know the listed veins!