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Preliminary External and Internal Dosimetry Data from a new set of mother/fetus models

Preliminary External and Internal Dosimetry Data from a new set of mother/fetus models. JY Zhang, V Taranenko, D Zhang, X. George Xu, Rensselaer Polytechnic Institute, Troy, NY CY Shi Cancer Therapy and Research Center, San Antonio, TX. Project Motivation (Pregnant Female Models).

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Preliminary External and Internal Dosimetry Data from a new set of mother/fetus models

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  1. Preliminary External and Internal Dosimetry Data from a new set of mother/fetus models JY Zhang, V Taranenko, D Zhang, X. George Xu, Rensselaer Polytechnic Institute, Troy, NY CY Shi Cancer Therapy and Research Center, San Antonio, TX

  2. Project Motivation(Pregnant Female Models) • High radio-sensitivity for the fetus • Needs for accurate dosimetry • Occupational (if the pregnancy is declared) • Nuclear medicine • Radiation treatment of pregnant patients (increasing!) • Air traveling • non-ionizing radiation (RF etc) • Models difficult to develop • Twice as many tissues and organs • 3-month, 6-month and 9-month gestational periods • Medical images are rare

  3. Project Goals 1) Development a new set of models of pregnant mother and fetus at the end of 3-, 6- and 9-month gestational periods 2) Compile organ dose parameters for external and internal irradiations

  4. Existing Pregnant Female Models • Stylized models • Stabin 1995 • Chen 2004 From partial-body CT image set - Shi and Xu (2004) They are un-realistic and in-complete

  5. Method:Flow Chart of Pregnant Female Model Development Model Extraction of 3D representation from CT Images (external uterine wall). This is a new approach!

  6. Organ Masses Adjusted to ICRP References

  7. From Surfaces to Voxels Re-voxelize at any size (1mm shown here) Put into MC codes - MCNPX - EGSnrc Surface Model Adjusted to ICRP reference values Geometry in MCNPX code Voxel Model

  8. RPI-P3, RPI-P6, and RPI-P9 Models 9-month 3-month 6-month

  9. Results - Internal photon Specific Absorbed Fractions(RPI-P9 phantom)

  10. Results - External photonsRPI-P9 phantom; total fetal dose

  11. Conclusion • A series of pregnant female and fetus phantoms have been developed • Organ masses are adjusted according to ICRP reference values • External photon, electron, neutron and proton sources have been studied • Internal photon and electron sources have been studied • ICRP is hoped to adopt the RPI-P series as standard pregnant-female models

  12. Acknowledgements • This work is supported by grants 1R42CA115122-01 and 5R01CA116743-03 from the National Institutes of Health • Drs Mike Stabin and Keith Eckerman provided valuable help on • ICRP data analysis Visualization for RPI-P9 Pregnant Female Model (available at RRMDG.rpi.edu)

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