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Lassa Fever. by Carly Brown. Discovery. John Frame 1969 collaborated with Yale Arbovirus Research Unit. Type/Structure. Arenaviridae family spherical lipid membrane single-stranded RNA. Transportation. zoonotic host-multimammate rat genus Mastomys person to person.
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Lassa Fever • by Carly Brown
Discovery • John Frame • 1969 • collaborated with Yale Arbovirus Research Unit
Type/Structure • Arenaviridae family • spherical • lipid membrane • single-stranded RNA
Transportation • zoonotic • host-multimammate rat • genus Mastomys • person to person
Transportation(cont.) • urine & droppings • direct contact • airborne transmission
Demographic Info. • at risk- those who live in areas with Mastomys rodents
Statistics • 100,000 - 300,000 infections a year • 5,000 deaths • accounts for 10-16% admitted to hospitals
Facts • 80% - no observable symptoms • 20% - severe multisystem disease • 1-3 weeks after contracted
Symptoms • fever • malaise • throat lesions • pneumonia • abdominal pain • vomiting • diarrhea
Symptoms(etc.) • retrosternal pain • back pain • cough • conjunctivitis • facial swelling • mucosal bleeding
Neurological Problems • tremors • hearing loss • deafness occurs in 1/3 of cases
Miscellaneous • 15-20% patients hospitalized die • 95% fetuses die • risky-women in 3rd trimester
Ribavirin • antiviral drug • used with success