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Lassa Fever

. General Facts. Viral hemorrhagic fever caused by the Arenavirus LassaTransmitted from rodents to humansDiscovered in Nigeria, 1969Endemic in portions of West AfricaSeasonal clustering: Late rainy and early dry seasonAffects all age groups and both sexes. . Arenaviridae. Name derived from

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Lassa Fever

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    1. Lassa Fever Special Pathogens Branch NCID/DVRD CDC

    2. General Facts Viral hemorrhagic fever caused by the Arenavirus Lassa Transmitted from rodents to humans Discovered in Nigeria, 1969 Endemic in portions of West Africa Seasonal clustering: Late rainy and early dry season Affects all age groups and both sexes

    3. Arenaviridae Name derived from arenosus (Latin sandy) describing appearance of virions on examination by electron microscopy Enveloped virus, round or pleomorphic, 50-300 nm in diameter Single-stranded genome divided into 2 RNA segments: small (~3.4 kb) and large (~7.1 kb) 2 genes on each segment, arranged in unique ambisense orientation, encoding 5 proteins Inactivated by: heating to 56oF pH<5.5 or >8.5 UV/gamma irradiation detergents

    4. Arenaviridae Arenaviruses associated with human disease Virus Origin of Name Year Distribution Lassa Town, Nigeria 1969 West Africa Junin Town, Argentina 1957 South America Machupo River, Bolivia 1962 South America Guanarito Area, Venezuela 1989 South America Sabia Town, Brazil 1990 South America LCMV Clinical disease 1933 Worldwide

    5. Lassa Virus

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