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+. +. Two parallel mechanisms in the basal ganglia. In parallel with the CD- SNr -SC serial inhibitions are present pathways mediated by the GPe and/or STN. Inhibitory and excitatory neurons are indicated by solid and open circles, respectively .
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Two parallel mechanisms in the basal ganglia. In parallel with the CD-SNr-SC serial inhibitions are present pathways mediated by the GPe and/or STN. Inhibitory and excitatory neurons are indicated by solid and open circles, respectively. The effects of the GPe/STN path-ways are thought to be opposite to that of the CD-SNr-SC pathway, since they contain two (CD and GPe) or no inhibitions before reaching theSNr. DA neurons in the SNc (and surrounding midbrain regions) connect mainly to striatal output neurons and exert modulatory effects, mostly via D1 receptors on SNr projecting neurons and via D2 receptors onGPe-projecting neurons. It is postulated that the corticostriatal input carries spatial information while the DA input carries reward-related information.
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