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Lecture 4

Lecture 4. CHE 618. Membrane transport Role of pH Solvents Metabolism and transport. Concentration (molarity, …). Fick’s Law. Flux. Permeability, m/s. Diffusion-limited mechanism:. J diff = D m /l m ([M] m,s ) [M] m,s = K ex [M] J diff = D m /l m • K ex [M] P = (D m K ex )/l m.

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Lecture 4

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  1. Lecture 4 CHE 618

  2. Membrane transport Role of pH Solvents Metabolism and transport

  3. Concentration (molarity, …) Fick’s Law Flux Permeability, m/s

  4. Diffusion-limited mechanism: Jdiff = Dm/lm ([M]m,s) [M]m,s = Kex[M] Jdiff = Dm/lm• Kex[M]P = (DmKex)/lm permeability

  5. Js = Ds/ls ([M]s - [M]m,s) Jin = k1[M]m,s - k-1[M]m,sJdiff = Dm/lm ([M]m,s - [M]m,r)Jout = -k1[M]m,r + k-1[M]m,r Jr = Dr/lr ([M]m,r - [M],r)

  6. Solvent-facilitated transport DMSO b.p. 189 C Poly(ethylene oxide) Carrier – facilitated transport

  7. Active transort Ion channels and ion pumps

  8. First-order process First-order elimination kinetics DRUG half-life(hours) Penicillin 0.5 Insulin 0.7 Aspirin 6 Tetracycline 9 Sulfadimethoxine 30 Vitamin D 40

  9. log C log C One-compartment kinetics Two-compartment kinetics time time

  10. First order consecutive process [B] time

  11. 0.05-0.10 mg/mL cocaine ¼ mg /mL cocaine

  12. benzoylecgonine Cocaethylene Ecgonine Methylecgonine 3-hydroxy-8-methyl-8-azabicyclo [3.2.1]octane-2-carboxylic acid H

  13. Cocaine metabolic profile. BE-benzoylecgonine, EME-ecgonine methyl ester,CE- cocethylene

  14. 6-MAM

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