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The Role of Hemoglobin in Regulation of Oxygen and Carbon Dioxide

The Role of Hemoglobin in Regulation of Oxygen and Carbon Dioxide. ENGS166 – Spring 2008 Presentation1 Amir Golnabi. Introduction:. Oxygen: Critical to support metabolism No storage system for oxygen → constant supply Oxygen transport: Hemoglobin

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The Role of Hemoglobin in Regulation of Oxygen and Carbon Dioxide

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  1. The Role of Hemoglobin in Regulation of Oxygen and Carbon Dioxide ENGS166 – Spring 2008 Presentation1 Amir Golnabi

  2. Introduction: Oxygen: Critical to support metabolism No storage system for oxygen → constant supply Oxygen transport: Hemoglobin 280 million Hemoglobin molecules are carried in one RBC: Hemoglobin is a large protein Very large surface area → water attraction → changing the structure and function of the hemoglobin Osmotic pressure in the vascular system Coagulate of hemoglobin in some organs such as liver

  3. Structure: α and β globin subunits: 141 vs 146 amino acids Each globin subunit is bound to a Heme molecule Heme: carbon, nitrogen, and hydrogen atoms, with a single iron ion at the center of the ring: Oxygen attracting property Red color of hemoglobin: Oxygen oxidizes the iron ion Hemoglobin Animation http://omlc.ogi.edu/spectra/hemoglobin/hemestruct/heme-struct.gif

  4. Function: Partial pressure of oxygen in lungs vs in tissues Oxyhemoglobin Oxygen-hemoglobin dissociation curve Example: at rest=40 mmHg doing exercise = 30 mmHg Sat. drops from 70% to 40% i.e. release more oxygen Sigmoidal Shape: cooperative binding http://www.md.rcm.upr.edu/physiology/images/O2saturation2.gif

  5. Regulation Factors: Amount of PH Temperature During exercise: right shift conformational change of hemoglobin: Releasing more oxygen Carbon dioxide removal www.unm.edu/~lkravitz/Media/oxygencurve.jpg

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