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BRCA1

Supplement Figure 1. HeLa. 293T. 2. 2. RLU. RLU. 1. 1. 0. 0. -. -. +. +. +. +. BRCA1. BRCA1. -. -. -. -. +. +. SUMO1. SUMO1. Supplement Figure 2. RLU. W. W. mock. V412A. V412A. BRCA1. V412/415A. V412/415A. I783/V788A. I783/V788A. V412/I783/V788A.

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BRCA1

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  1. Supplement Figure 1 HeLa 293T 2 2 RLU RLU 1 1 0 0 - - + + + + BRCA1 BRCA1 - - - - + + SUMO1 SUMO1

  2. Supplement Figure 2 RLU W W mock V412A V412A BRCA1 V412/415A V412/415A I783/V788A I783/V788A V412/I783/V788A V412/I783/V788A + SUMO1 None

  3. Before IP Before IP IP : BRCA1 IP : BRCA1 + + + + + + + + HDAC1 HDAC2 - - - - + + + + SUMO1 SUMO1 Supplement Figure 3 Before IP IP : BRCA1 + + + + BARD1 - - + + SUMO1 Anti-BRCA1 Anti-BARD1 Before IP IP : BRCA1 + + + + p300 - - + + SUMO1 Anti-BRCA1 Anti-p300 Anti-BRCA1 Anti-HDAC1 Anti-BRCA1 Anti-HDAC2

  4. Supplement Figure 4 8 11 BRCA1#1 2 DLSALR VEEV QNVI 15 90 83 BRCA1#1 72 SLQESTRFSQLVEELLKII 90 416 419 429 432 BRCA1#2416 LNEV DEYSGSSEK IDLL ASD435 623 626 BRCA1#3 615 SSTRHIHA LELVVS628

  5. Supplement Figure 5 MDA-MB-231 HMEC#11 HMEC#6 Hs578T MCF7 Anti-BRCA1 Anti-SUMO-1 Anti-actin HMEC MCF7 WI38 VA13 - - - - -irradiation -irradiation + + + + Anti-SUMO-1 Anti-SUMO-1 Anti-actin Anti-actin

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