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BRCA1

BRCA1. Breast Cancer. BRCA1 has many binding domains and thus involved with several complexes with distinct functions. Steven A. Narod & William D. Foulkes, 2004. BRCA1 functions with multiple proteins. Kevin W. Caestecker, Gerlinde R. Van de Walle, 2012.

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BRCA1

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  1. BRCA1 Breast Cancer

  2. BRCA1 has many binding domains and thus involved with several complexes with distinct functions Steven A. Narod & William D. Foulkes, 2004

  3. BRCA1 functions with multiple proteins Kevin W. Caestecker, Gerlinde R. Van de Walle, 2012

  4. BRCA1 as a DNA damage repair protein in homologous recombination Lea M Starita, Jeffrey D Parvin, 2003

  5. Homologous Recombination http://www.sci.sdsu.edu/~smaloy/MicrobialGenetics/topics/genetic-analysis/recombination/rec-molecular.html

  6. BRCA1-/- in mice causes embryonic lethality; growth retardation, apoptosis, cell cycle defects, and genomic instability Razqallah Hakem et al, 1996

  7. 5-10% of total breast cancers have hereditary disposition • Can have up to 80% risk of being diagnosed with breast cancer during lifetime if have mutation (as opposed to 12%)

  8. Tumor formation is result of additional mutations that promote growth advantage Deng CX 2002

  9. BRCA1 mutations inherited autosomal dominant in pedigree http://www.uvm.edu/~cgep/Education/Inheritance2.html

  10. Targeted therapies target PARP enzyme Joseph A. De Soto, Chu-Xia Deng 2006

  11. Sources • Steven A. Narod & William D. Foulkes, 2004 • Kevin W. Caestecker, Gerlinde R. Van de Walle, 2012 • Razqallah Hakem et al, 1996 • Deng CX, 2002 • Joseph A. De Soto, Chu-Xia Deng, 2006 • http://www.uvm.edu/~cgep/Education/Inheritance2.html • http://www.sci.sdsu.edu/~smaloy/MicrobialGenetics/topics/genetic-analysis/recombination/rec-molecular.html

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