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Ziheng Yang

Aidan Budd. Nick Goldman. Ziheng Yang. Bill Pearson. Alignment nekódující DNA (Ari Loytynoja). Koalescenční modely divergence populací. Radka Storchov á. Wright-Fisher model. Sewall Wright. Sir Ronald Fisher. Teorie koalescence. MRCA. John Kingman. Koalescenční modely.

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Ziheng Yang

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  1. Aidan Budd Nick Goldman Ziheng Yang Bill Pearson

  2. Alignment nekódující DNA(Ari Loytynoja)

  3. Koalescenční modely divergence populací Radka Storchová

  4. Wright-Fisher model Sewall Wright Sir Ronald Fisher

  5. Teorie koalescence MRCA John Kingman

  6. Koalescenční modely Isolation with Migration (IM) N1 N2 m1 m2 t NA

  7. Koalescenční modely Migrate, Lamarck m1 N1 N2 m2 m5 m3 m4 m6 N3

  8. Koalescenční modely MCMC coal N3 N1 N2 t1 t2 NA

  9. Aplikace „Isolation with Migration“ modelu na dva druhy slavíků N1 N2 m1 m2 t NA

  10. IM • Vstupní data • nukleotidové sekvence/mikrosatelity předpoklady - neutralita - žádná rekombinace v rámci lokusu - volná rekombinace mezi lokusy • mutační rychlost

  11. IM Odhad parametrů pomocí Markov Chain Monte Carlo (MCMC) simulací Příklad jak spustit IMa program: ima -i IM_input.txt -o IM_output5.out -q1 10 -m1 1.4 -m2 1.2 -t 4 -b 1000000 -l 1.0 -fg -n 15 -g1 0.8 -g2 0.9 -p1345 -s 634264

  12. IM Výstup3 simulace (1) pro všechny geny, (2) pro autosomální geny, (3) pro Z-vázané geny N m t all chrA chrZ

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