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Chapter 3: Non-Associative Learning and Memory

Chapter 3: Non-Associative Learning and Memory. From Mechanisms of Memory , second edition By J. David Sweatt, Ph.D. Cytoskeletal Rearrangement in Synaptic Plasticity. Hypothetical Graph of 32 P-PO 4. 32 P Incorporation into protein or adenine nucleotides. Steady State. 32 P added.

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Chapter 3: Non-Associative Learning and Memory

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  1. Chapter 3: Non-Associative Learning and Memory From Mechanisms of Memory, second edition By J. David Sweatt, Ph.D.

  2. Cytoskeletal Rearrangement in Synaptic Plasticity

  3. Hypothetical Graph of 32P-PO4 32P Incorporation into protein or adenine nucleotides Steady State 32P added Time (hrs) Figure 1

  4. AMPA Receptors A B C Figure 2

  5. Protein Turnover Isoelectic Point 10 3 High (approx 200 kDa) Molecular Weight Low (approx 5 kDa) Figure 3

  6. Actin Turnover Figure 4

  7. Aplysia californica Figure 5

  8. Siphon-gill and tail-siphon withdrawal reflexes of Aplysia Figure 6

  9. Short-term Sensitization of the gill-withdrawal reflex in Aplysia C Figure 7:

  10. Circuit Diagrams of the Siphon-gill Figure 8

  11. Heterosynaptic Facilitation of the Sensorimotor Figure 9

  12. Molecular events in Aplysia Figure 10

  13. Mechanisms of long-term memory formation Figure 11

  14. Shorter Term AMP cAMP Reg. Reg. Cat. Cat. PDE Reg. Cat. Reg. Cat. cAMP PKA Reg. Cat. Reg. Cat. Longer Term Altered Gene Expression and Substrates Ubiquitin-mediated proteolysis Cat. PO4 Substrates Cat. Facilitation of Neurotransmitter release Figure 12

  15. Aplysia Figure 13

  16. Cellular basis of behavior Figure 14

  17. The Eskin/ Byrne model in Aplysia long-term facilitation Figure 15

  18. Spinal Sensitization Behavioral Sensitization A. C. Before After Withdrawal Threshold paw stimulation paw stimulation Before After B. D. Before After Withdrawal Threshold paw stimulation paw stimulation Before After Injury-induced Spinal and Behavioral Sensitization Figure 16

  19. Cortex Thalamus Amygdala Hypothalamus Midbrain Ascending Pathways PAG Descending Pathways Withdrawal Reflex Pons RVM Medulla DRG Aδ-fiber C-fiber nociceptor terminals Spinal cord End-organ tissue Anatomical Pain Pathways Figure 17 Figure 17

  20. Coupling of Receptors to Intracellular Messengers The cAMP System The PLC System “Gs” Protein “Go” Protein Receptor Receptor α γ α γ PLC Adenylyl Cyclase β β GTP GDP GTP GDP ATP PIP2 cAMP Ca++ IP3 cAMP-Dependent Protein Kinase (PKA) DAG Cat. Reg PKC Ion Channels Cat. Reg PO4 PO4 Substrate Substrate Blue Box 1

  21. GFR PKC Rap1 Ras PKA Sos Grb2 AC B-Raf Raf-1 PKA MEK mapk p42 Effectors Potential Signal Transduction routes leading to MAPK Activation in Neurons Blue Box 2

  22. + + Regulation of RAS Inactive Active PO4 ras ras GTP Hydrolysis GDP GTP GAPs GTPase Activating Proteins e.g. NF1, SynGAP GTP GEFs Guanine Nucleotide Exchange Factor Proteins e.g. SOS, cAMP GEF, Ca2+/DAG GEF, ras GRF Blue Box 3

  23. Habituation and Synaptic Inhibition Blue Box 4

  24. A Preparation for swimming Contact Withdrawal B Swimming C Escape Swimming in Tritonia Blue Box 6

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