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Kashin -Beck Disease

Kashin -Beck Disease . Normal Bone Growth. Normal Bone Growth. Normal Bone Growth. Osteoblasts form. Normal Bone Growth. The cartilage is being vascularized . Osteoblasts begin the ossification process. . Normal Bone Growth. Primary ossification site. Normal Bone Growth.

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Kashin -Beck Disease

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  1. Kashin-Beck Disease

  2. Normal Bone Growth

  3. Normal Bone Growth

  4. Normal Bone Growth Osteoblasts form

  5. Normal Bone Growth The cartilage is being vascularized. Osteoblasts begin the ossification process.

  6. Normal Bone Growth Primary ossification site

  7. Normal Bone Growth Ossification center forms

  8. Normal Bone Growth Osteoblast lay down hydroxyapatite.

  9. Normal Bone Growth Secondary ossification site

  10. Normal Bone Growth Epiphyseal plate is where growth will occur.

  11. Normal Bone Growth Osteoblast lay down matrix, ossifying the cartilage of the epiphyseal plate. The chondrocytes continue laying down cartilage toward the epiphyseal end of the bone.

  12. Bone growth is occurring. As osteoblasts ossify the cartilage.

  13. Osteoclast follow, remodeling the bone: The circles represent osteoclastic remodeling. (It is the medullary cavity.)

  14. Osteoclasts continue remodeling the bone.

  15. Normal Bone Growth The process continues with chondroblasts laying down cartilage, ossification follows the osteoblasts until the osteoblasts overtake the chondroblasts. At this time, interstitial growth ceases.

  16. Normal Bone Growth

  17. Kashin-Beck Joint

  18. Kashin-Beck Joint Chondroblasts experience apoptosis or cell death. (aetiology is assumed to be selenium deficiency or fungal contamination of grain supplies)

  19. Kashin-Beck Joint This is thought to cause increased free radicals and ultimately cell death of the cartilage building cells.

  20. Kashin-Beck Joint Joint swells up

  21. Kashin-Beck Joint The bone length shrinks

  22. Kashin-Beck Joint Joint keeps swelling

  23. Kashin-Beck Joint

  24. A man with Kashin-Beck

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