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Kashin -Beck Disease . Normal Bone Growth. Normal Bone Growth. Normal Bone Growth. Osteoblasts form. Normal Bone Growth. The cartilage is being vascularized . Osteoblasts begin the ossification process. . Normal Bone Growth. Primary ossification site. Normal Bone Growth.
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Normal Bone Growth Osteoblasts form
Normal Bone Growth The cartilage is being vascularized. Osteoblasts begin the ossification process.
Normal Bone Growth Primary ossification site
Normal Bone Growth Ossification center forms
Normal Bone Growth Osteoblast lay down hydroxyapatite.
Normal Bone Growth Secondary ossification site
Normal Bone Growth Epiphyseal plate is where growth will occur.
Normal Bone Growth Osteoblast lay down matrix, ossifying the cartilage of the epiphyseal plate. The chondrocytes continue laying down cartilage toward the epiphyseal end of the bone.
Bone growth is occurring. As osteoblasts ossify the cartilage.
Osteoclast follow, remodeling the bone: The circles represent osteoclastic remodeling. (It is the medullary cavity.)
Normal Bone Growth The process continues with chondroblasts laying down cartilage, ossification follows the osteoblasts until the osteoblasts overtake the chondroblasts. At this time, interstitial growth ceases.
Kashin-Beck Joint
Kashin-Beck Joint Chondroblasts experience apoptosis or cell death. (aetiology is assumed to be selenium deficiency or fungal contamination of grain supplies)
Kashin-Beck Joint This is thought to cause increased free radicals and ultimately cell death of the cartilage building cells.
Kashin-Beck Joint Joint swells up
Kashin-Beck Joint The bone length shrinks
Kashin-Beck Joint Joint keeps swelling
Kashin-Beck Joint