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Alzheimer’s Disease

Alzheimer’s Disease. Diego, Jackie, and Pete 1/27/10 Period 2. Summary of Genetic Disorder. Alzheimer’s Disease is a progressive and fatal brain disease. Over 5 million people have it.

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Alzheimer’s Disease

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  1. Alzheimer’s Disease Diego, Jackie, and Pete 1/27/10 Period 2

  2. Summary of Genetic Disorder • Alzheimer’s Disease is a progressive and fatal brain disease. • Over 5 million people have it. • Early symptoms include memory loss, trouble concentrating, and inability to remember facts, events and later family and friends. • Alzheimer’s disease is the 4th leading cause of death in adults. • AD is twice as common in women than it is in men.

  3. Affected Chromosomes • Alzheimer’s affects the 1st, 14th, 19th, and 21st chromosomes.

  4. Mode of Inheritance • Alzheimer’s does have a genetic link, and it is a Dominant disorder. • FAD (Familial Alzheimer's Disease) occurs in a very small percentage of people with Alzheimer's disease (5-7%) • Sporadic Alzheimer's Disease is much more common (around 90-95 %) and people with this type do not necessarily have a family history of the disease.

  5. Alleles • An allele is an alternative form of a gene (one member of a pair) that is located at a specific position on a specific chromosome. • Humans have 2 alleles per gene. • The two alleles come from both parents. • Recessive alleles are represented by rr. Dominant alleles are represented by RR or Rr. • Phenotypes are specified by single gene substitutions are called Dominants and those that require homozygous combinations for expression are called recessives.

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