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Coeliac Disease

Coeliac Disease. 1% UK population 3% Pts presenting with “IBS” symptoms Minimal/atypical symps 2:1 female – male Smoking protective. Coeliac Serology. Antigliadin Ab Assays – obsolete IgA Endomyseal Ab (EMA) IgA TTG Ab – beware IgA deficiency Highly sensitive & specific

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Coeliac Disease

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  1. Coeliac Disease • 1% UK population • 3% Pts presenting with “IBS” symptoms • Minimal/atypical symps • 2:1 female – male • Smoking protective

  2. Coeliac Serology • Antigliadin Ab Assays – obsolete • IgA Endomyseal Ab (EMA) • IgA TTG Ab – beware IgA deficiency • Highly sensitive & specific Good screening test for Coeliac Disease

  3. Diagnosis • Serology +/Histology+Coeliac Disease • Serology +/Histology -Review/repeat bx 1yr • Serology-/Histology+ Consider other causes enteritis.If none treat as Coeliac • Serology-/Histology- Diagnosis excluded

  4. Management • GFD – most can eat oats • Screen for and manage osteoporosis • Persistent symps – check diet, think of other things • Refractory Coeliac – low-grade lymphoma

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