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LUNG TRANSPLANTATION

LUNG TRANSPLANTATION. Pediatric Recipients. ISHLT. 2008. J Heart Lung Transplant 2008;27: 937-983. RECIPIENT AGE DISTRIBUTION FOR PEDIATRIC LUNG RECIPIENTS - NUMBER (Transplants: January 1986 - June 2006). ISHLT. 2008. J Heart Lung Transplant 2008;27: 937-983.

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LUNG TRANSPLANTATION

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  1. LUNG TRANSPLANTATION Pediatric Recipients ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  2. RECIPIENT AGE DISTRIBUTION FOR PEDIATRIC LUNG RECIPIENTS - NUMBER (Transplants: January 1986 - June 2006) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983 Last updated based on data as of December 2006

  3. RECIPIENT AGE DISTRIBUTION FOR PEDIATRIC LUNG RECIPIENTS - PERCENTAGE(Transplants: January 1986 - June 2006) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983 Last updated based on data as of December 2006

  4. DONOR TYPE DISTRIBUTION BY YEAR OF TRANSPLANT FOR PEDIATRIC LUNG RECIPIENTS (Transplants: 1986-2006) ISHLT NOTE: This figure includes only the lung transplants that are reported to the ISHLT Transplant Registry. As such, this should not be construed as evidence that the number of lung transplants worldwide has declined in recent years. 2008 J Heart Lung Transplant 2008;27: 937-983

  5. DONOR TYPE DISTRIBUTION BY RECIPIENT AGE GROUP WITHIN ERA FOR PEDIATRIC LUNG RECIPIENTS (Transplants: January 1986 - June 2006) ISHLT 2008 Last updated based on data as of December 2006 J Heart Lung Transplant 2008;27: 937-983

  6. AGE DISTRIBUTION FOR DONORS OFPEDIATRIC LUNG RECIPIENTS(Transplants: January 1986 - June 2006) ISHLT 2008 Last updated based on data as of December 2006 J Heart Lung Transplant 2008;27: 937-983

  7. 85 86 84 83 AGE DISTRIBUTION OF PEDIATRIC LUNG RECIPIENTSBy Year of Transplant 75 75 73 72 68 67 67 58 51 49 47 44 Number of Transplants 20 6 4 3 1 ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  8. NUMBER OF CENTERS REPORTING PEDIATRIC LUNG TRANSPLANTS ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  9. NUMBER OF CENTERS REPORTING PEDIATRIC LUNG TRANSPLANTS BY CENTER VOLUME ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  10. PEDIATRIC LUNG TRANSPLANTATION: Indications (Transplants: January 1990 – June 2006) ISHLT 2008 Last updated based on data as of December 2006 J Heart Lung Transplant 2008;27: 937-983

  11. PEDIATRIC LUNG TRANSPLANTATION:Other Indications (Transplants: January 1990 – June 2006) ISHLT 2008 Last updated based on data as of December 2006 J Heart Lung Transplant 2008;27: 937-983

  12. PEDIATRIC LUNG TRANSPLANTATION: Other Indications (Transplants: January 1990 – June 2006) ISHLT 2008 Last updated based on data as of December 2006 J Heart Lung Transplant 2008;27: 937-983

  13. PEDIATRIC LUNG TRANSPLANTATION: Other Indications (Transplants: January 1990 – June 2006) ISHLT 2008 Last updated based on data as of December 2006 J Heart Lung Transplant 2008;27: 937-983

  14. DIAGNOSIS IN PEDIATRIC LUNG RECIPIENTSBY YEAR OF TRANSPLANTAge: 12-17 Years ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  15. PEDIATRIC LUNG TRANSPLANTS:AGE DISTRIBUTION BY LOCATIONTransplants between January 2000 and June 2006 ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983 Last updated based on data as of December 2006

  16. PEDIATRIC LUNG TRANSPLANTS:DIAGNOSIS DISTRIBUTION BY LOCATIONTransplants between January 2000 and June 2006 • NOTE: Unknown diagnoses were excluded from this tabulation. • Total number of transplants reported: • Europe = 82 • North America = 338 • Other = 24 ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983 Last updated based on data as of December 2006

  17. PEDIATRIC LUNG TRANSPLANTS:DONOR AGE DISTRIBUTION BY LOCATIONTransplants between January 2000 and June 2006 • NOTE: Transplants with unknown donor age were excluded from this tabulation. • Total number of transplants reported: • Europe = 82 • North America = 338 • Other = 24 ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983 Last updated based on data as of December 2006

  18. LUNG TRANSPLANTATIONKaplan-Meier Survival by Age Group (Transplants: January 1990 - June 2006) P = 0.6539 ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  19. PEDIATRIC LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type (Transplants: January 1990 - June 2005) P < .0001 ISHLT 2008 Last updated based on data as of December 2006 J Heart Lung Transplant 2008;27: 937-983

  20. PEDIATRIC LUNG TRANSPLANTATIONKaplan-Meier Survival for Congenital Diagnoses(Transplants: January 1990 – June 2005) Eisenmenger’s vs. Other: p = 0.19 ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983 Last updated based on data as of December 2006

  21. PEDIATRIC LUNG TRANSPLANTATIONKaplan-Meier Survival by Age Group (Transplants: January 1990 - June 2006) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  22. PEDIATRIC LUNG TRANSPLANTATIONConditional Kaplan-Meier Survival by Age Group(Transplants: January 1990 - June 2006) CONDITIONAL HALF-LIFE <1 Year: 12.1 Years 1-11 Years: 10.5 Years 12-17 Years: 6.1 Years ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  23. PEDIATRIC LUNG TRANSPLANTATION Kaplan-Meier Survival by Era (Transplants: January 1988 - June 2006) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  24. PEDIATRIC LUNG TRANSPLANTATIONKaplan-Meier Survival by Donor Type for Recipients Age 12-17 Years(Transplants: January 1990 - June 2005) HALF-LIFE Deceased: 4.0 Years Living: 3.8 Years ISHLT 2008 Last updated based on data as of December 2006 J Heart Lung Transplant 2008;27: 937-983

  25. PEDIATRIC LUNG RE-TRANSPLANTS Between January 1994 and June 2006 Time Between Previous and Current Transplant ISHLT 2008 Last updated based on data as of December 2006 J Heart Lung Transplant 2008;27: 937-983

  26. PEDIATRIC LUNG RETRANSPLANTSSurvival for Transplants Performed Between January 1994 and June 2006 ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  27. PEDIATRIC LUNG RECIPIENTS Functional Status of Surviving Recipients(Follow-ups: April 1994-June 2006) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983 Last updated based on data as of December 2006

  28. PEDIATRIC LUNG RECIPIENTS Rehospitalization Post-transplant of Surviving Recipients(Follow-ups: April 1994 - June 2006) ISHLT 2008 Last updated based on data as of December 2006 J Heart Lung Transplant 2008;27: 937-983

  29. PEDIATRIC LUNG RECIPIENTS Rehospitalization Post-transplant of Surviving Recipients(Follow-ups: April 1994 - June 2006) ISHLT 2008 Last updated based on data as of December 2006 J Heart Lung Transplant 2008;27: 937-983

  30. PEDIATRIC LUNG RECIPIENTS Induction ImmunosuppressionFor transplants between January 2001 and June 2007 ISHLT 2008 Analysis is limited to patients who were alive at the time of the follow-up J Heart Lung Transplant 2008;27: 937-983

  31. PEDIATRIC LUNG RECIPIENTSInduction Immunosuppression (Transplants: January 2001 - June 2007) ISHLT 2008 Analysis is limited to patients who were alive at the time of the follow-up J Heart Lung Transplant 2008;27: 937-983

  32. PEDIATRIC LUNG TRANSPLANTATIONKaplan-Meier Survival Stratified by Induction Use(Transplants: January 2001 - June 2006) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  33. PEDIATRIC LUNG RECIPIENTSMaintenance Immunosuppression at Time of Follow-up(Follow-ups: January 2001 and June 2007) NOTE: Different patients are analyzed in Year 1 and Year 5 ISHLT 2008 Analysis is limited to patients who were alive at the time of the follow-up J Heart Lung Transplant 2008;27: 937-983

  34. PEDIATRIC LUNG RECIPIENTSMaintenance Immunosuppression at Time of Follow-up(Follow-ups: January 2001 and June 2007) 1 Year Follow-up (N = 244) 5 Year Follow-up (N = 116) NOTE: Different patients are analyzed in Year 1 and Year 5 NOTE: 3% of patients were on both calcineurin inhibitors at different point during the year; these patients are not counted in either group. And 1% (2 patients) were on neither drugs during the year. In the 5-year tabulations, 16% were reported to be on both drugs during the year and 1% (1 patient) were reported to be on neither drugs. ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983 Analysis is limited to patients who were alive at the time of the follow-up

  35. PEDIATRIC LUNG RECIPIENTSMaintenance Immunosuppression Drug Combinations at Time of Follow-up Report (Follow-ups: January 2001 and June 2007) NOTE: Different patients are analyzed in Year 1 and Year 5 ISHLT 2008 Analysis is limited to patients who were alive at the time of the follow-up J Heart Lung Transplant 2008;27: 937-983

  36. POST-LUNG TRANSPLANT MORBIDITY FOR PEDIATRICSCumulative Prevalence in Survivors within 1 Year Post-Transplant (Follow-ups: April 1994 - June 2006) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983 Last updated based on data as of December 2006

  37. POST-LUNG TRANSPLANT MORBIDITY FOR PEDIATRICSCumulative Prevalence in Survivors within 5 Years Post-Transplant (Follow-ups: April 1994 - June 2006) ISHLT 2008 Last updated based on data as of December 2006 J Heart Lung Transplant 2008;27: 937-983

  38. POST-LUNG TRANSPLANT MORBIDITY FOR PEDIATRICSCumulative Prevalence in Survivors within 7 Years Post-Transplant (Follow-ups: April 1994 - June 2006) ISHLT 2008 Last updated based on data as of December 2006 J Heart Lung Transplant 2008;27: 937-983

  39. Freedom from Bronchiolitis ObliteransFor Pediatric Lung Recipients(Follow-ups: April 1994 - June 2007) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  40. FREEDOM FROM BRONCHIOLITIS OBLITERANSFor Pediatric Lung Recipients by Induction Use (Follow-ups: April 1994 - June 2007) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

  41. Freedom from Severe Renal Dysfunction*For Pediatric Lung Recipients(Follow-ups: April 1994 - June 2006) * Severe renal dysfunction = Creatinine > 2.5 mg/dl (221 μmol/L), dialysis or renal transplant ISHLT 2008 Last updated based on data as of December 2006 J Heart Lung Transplant 2008;27: 937-983

  42. MALIGNANCY POST-LUNG TRANSPLANTATION FOR PEDIATRICSCumulative Incidence for Survivors(Follow-ups: April 1994 - June 2006) ”Other” includes Liver and primitive neuroectodermal tumor. ISHLT 2008 Last updated based on data as of December 2006 J Heart Lung Transplant 2008;27: 937-983

  43. Freedom from MalignancyFor Pediatric Lung Recipients (Follow-ups: April 1994 - June 2006) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983 Last updated based on data as of December 2006

  44. PEDIATRIC LUNG TRANSPLANT RECIPIENTS: Cause Of Death(Deaths: January 1992- June 2006) ISHLT 2008 Last updated based on data as of December 2006 J Heart Lung Transplant 2008;27: 937-983

  45. PEDIATRIC LUNG TRANSPLANT RECIPIENTS: Other Cause Of Death(Deaths: January 1992- June 2006) ISHLT 2008 Last updated based on data as of December 2006 J Heart Lung Transplant 2008;27: 937-983

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