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November 4, 2011

NCI’s Physical Sciences – Oncology Centers Program: Evaluating trans-Disciplinary Collaborations and Field Convergence. Larry A. Nagahara, PhD, Director, OPSO Nicole Moore, ScD, Project Manager, OPSO.

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November 4, 2011

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  1. NCI’s Physical Sciences – Oncology Centers Program:Evaluating trans-Disciplinary Collaborations and Field Convergence Larry A. Nagahara, PhD, Director, OPSO Nicole Moore, ScD, Project Manager, OPSO Office of Physical Sciences - Oncology, Center for Strategic Scientific Initiatives (CSSI), National Cancer Institute (NCI), National Institutes of Health (NIH) November 4, 2011

  2. Physical Scientist & Cancer Biologist How can I culture Physical Scientists & Cancer Biologists to work together? Max Delbrück • “helped many physicists make the transition to biology” • They encouraged other investigators in the field to concentrate on seven bacteriophages ... That way, experimental results from different laboratories could be compared.

  3. PS-OC Program Goal and Vision • The Specific Purpose for the PS-OC Initiative: • To generate new knowledgeand catalyze new fields of studyin cancer research by utilizing physical sciences/engineering principles to enable a better understanding of cancer and its behavior at all scales. • Not looking for new tools to do “better” science, but new perspectives and approaches to do paradigm-shifting science that will lead to exponential progress against cancer. • Build trans-disciplinary teams and infrastructure to better understand and control cancer through the convergence • of physical sciences and cancer biology. New – “Schools of Thought”

  4. PS-OC Network: Physical scientists & cancer biologists/oncologists integrated at the start O’Halloran Licht Liphardt Weaver Shuler Hempstead van Oudenaarden Jacks UC Berkeley MIT Cornell Northwestern Hillis Agus Michor Holland USC DFCI Princeton Scripps PS-OC Network Austin Tlsty Kuhn Bethel Moffitt ASU TMHRI Johns Hopkins Davies Grady Ferrari Curley Gatenby Gillies Wirtz Semenza

  5. PS-OC Mechanism • U54 (Cooperative Agreement Specialized Center) • Facilitate and enable the convergence of the physical sciences with cancer biology/clinical oncology to understand cancer at a fundamental level. • Active coordination by program managers trained in physical and cancer sciences. • Accelerate ‘cycle of learning’ through shared resource core facilities. • Provide linkages to key NCI programs and resources

  6. Core B Core B Core A Core A Trans- Network Projects Outreach and Dissem Unit Outreach and Dissem Unit PS-OC Operation: Interactions Inside and Outside of Network PS-OC Network External Research Communities PS-OC Organizing Framework Pilot Projects Project 1 Project 2 Project 3 Project 4 Trans-Network Admin Unit Outreach Projects Education and Training Unit Education and Training Unit Trainee Exchange Trans-Network Admin Unit Outreach Projects Pilot Projects Organizing Framework PS-OC Project 1 Project 2 Project 3 Project 4

  7. Prospective Evaluation of PS-OCs Unique Program Unique Evaluation • Goal:Collect data during the Program for ongoing monitoring and feedback • Are the Program’s objectives and priorities being met by progress to date? • Bring physical scientists to cancer research • Form trans-disciplinary teams • Convergence of Physical Sciences and Oncology fields • Paradigm shifting science • What aspects of the Program should be changed? • Does the potential for future progress merit continued investment by NCI in the PS-OCs?

  8. Data Collection of Network • Data Collection Methods: • Interviews with Investigators prior to start of program • Progress Reports • Progress of research towards aims • All personnel list • Publications, Presentations, Patents • List of trainees (including discipline) • Student exchanges and transitions • New collaborations within Center, within Network, or outside Network • Information collected from Investigators outside progress reports Semi-Annual ~70-80 pages 3 reports to date

  9. Data Model • Visual representation of the structure of the progress report data • Used to formally describe data relationships Example relationships: • Which peoplecontributedto a project? • Which projects does a progress report identify? • Which publications has a person written?

  10. Data Model Diagram

  11. SQL Database • Stores data entered through the Data Entry User Interface • Entered data can be queried to support charting and data export in the Analysis User Interface Data Entry User Interface Database

  12. iTRAQR – Phase 1

  13. Evaluation Metrics • Investigators and Trainees • Network and Center Collaborations • Trans-Disciplinary Authorship Collaborations • Field Convergence (Physical Sciences/Oncology) • Time series analysis of Physical Sciences and Oncology term concurrent in the literature • Types of publications that investigators are generating • Types of journals that investigators are publishing (before/after)

  14. PS-OC Network: Who?Network Trainees and Investigators Trainees Investigators Physical Sciences Cancer Biology Both Both Physical Scientist and Cancer Biologists at all levels Trainees = Undergraduates, Graduates, Post-Doc, Research Associate, Medical Student

  15. PS-OC Network: How do we interact?Network Level - June 2011 Annual Report Project/Core Collaborations Reported by one PSOC (68) Project/Core Collaborations Reported by both PSOC (15)

  16. PS-OC Network: How do we interact?Center Level Examples of 3 PS-OC Center Interactions UC Berkeley PS-OC Cornell PS-OC Princeton PS-OC Each PS-OC is unique in the structure and degrees of interactions between Research Projects

  17. Trans-Disciplinary CollaborationsAnalysis of Authorship Collaborations PS-OC Investigator Collaborations Pre-Award (2000-2008) vs. Post-award (2009 - present) 19 per year Node: Network PI (Physical Scientist,Oncologist) Line: Network Co-authorship PI pair (PS-PS,OC-OC,PS-OC)

  18. Trans-Disciplinary CollaborationsAnalysis of Authorship Collaborations PS-OC Investigator Collaborations Pre-Award (2000-2008) vs. Post-award (2009 - present) Analysis of Collaborations 19 per year 62 per year 8% increase in trans-disciplinary authorship collaborations since the start of the PS-OC program Physical Sciences PIs Physical Sciences & Cancer PIs Node: Network PI (Physical Scientist,Oncologist) Line: Network Co-authorship PI pair (PS-PS,OC-OC,PS-OC) Cancer PIs

  19. Field ConvergenceSet of Cleaned MeSH Terms Journal Category Physical Sciences MeSH Terms Physical Sciences Journals Cancer Journals 843 695 109 Publications Publications MeSH Terms MeSH Terms Cancer MeSH Terms Non-Descriptive Terms Physical Sciences Terms Cancer Terms

  20. Field ConvergenceAnalysis of PS-OC Investigators Publications Use sets of MeSH terms to categorize PS-OC investigator publications ? Start of PS-OC program (September 2009)

  21. Field ConvergenceAnalysis of PS-OC Investigators Publications Physical Sciences PIs Cancer Biology PIs Physical Sciences Cancer Physical Sciences & Cancer Non-Descriptive

  22. Physical Sciences in Oncology (physics.cancer.gov) More Information Larry A. Nagahara, Ph.D.Email:  larry.nagahara@nih.gov Nicole M. Moore, Sc.D. Email: nicole.moore@nih.gov Nastaran Z. Kuhn, Ph.D. Email: Nastaran.kuhn@nih.gov Sean E. Hanlon, Ph.D Email: hanlonse@mail.nih.gov Mariam Eljanne, Ph.D. Email: mariam.eljanne@nih.gov

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