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Yellow Fever

Yellow Fever. March 29, 2012 Aaron Dinerman. Yellow Fever in Today’s World. 200,000 Cases/Year 30,000 Deaths/Year. Symptoms/Presentation. Phase 1 Phase 2 (Variable) Phase 3 (Variable; 15% of Patients reach this point). Yellow Fever originated from Africa….

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Yellow Fever

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  1. Yellow Fever March 29, 2012 Aaron Dinerman

  2. Yellow Fever in Today’s World • 200,000 Cases/Year • 30,000 Deaths/Year

  3. Symptoms/Presentation • Phase 1 • Phase 2 (Variable) • Phase 3 (Variable; 15% of Patients reach this point)

  4. Yellow Fever originated from Africa….

  5. First Recorded Outbreak: 1648 “Xekik” = “Black Vomit”

  6. Worldwide Spread “Yellow Jack”

  7. Wilmington, NC and Yellow Fever

  8. The Walter Reed Commission of 1900 and “The Mosquito Hypothesis”

  9. THIS GUY, AGAIN.

  10. BUT…. Yellow Fever ≠ Malaria

  11. A Capsid Flavivirus with an Envelope “Flavus” = Latin for “Yellow”

  12. Note the different binding domains for the various cleaved proteins (early virus assembly)

  13. The Viral Life Cycle: Overall Body Effect

  14. Epidemiological Cycles

  15. Detection/Diagnosis

  16. Prevention/Vaccination

  17. Protease Inhibitors as a Possible Therapeutic Drug? This approach is like that of the HIV protease inhibitor paper

  18. Sources • http://ncpedia.org/history/health/yellow-fever • http://www.infectionlandscapes.org/2011/07/yellow-fever.html • http://www.who.int/mediacentre/factsheets/fs100/en/ • http://en.wikipedia.org/wiki/Yellow_fever#History • http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002341/ • http://vir.sgmjournals.org/content/88/8/2223.full.pdf • http://www.med.yale.edu/micropath/pdf/Lindenbach2007.pdf

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