1 / 15

YELLOW FEVER

YELLOW FEVER. EPIDEMIOLOGY 1. YF is an acute haemorrhagic fever caused by the YF virus - an RNA virus which belongs to the genus of FLAVIVIRUSES. (arbovirus) 2 forms are known:

marc
Download Presentation

YELLOW FEVER

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. YELLOW FEVER DR (MRS) M.B. FETUGA

  2. EPIDEMIOLOGY 1 • YF is an acute haemorrhagic fever caused by the YF virus - an RNA virus which belongs to the genus of FLAVIVIRUSES. (arbovirus) • 2 forms are known: -Urban form: Direct man-to-man transmission by the Aedes aegypti mosquitoes which breed in pots and cans around houses. -Jungle form: Zoonotic infection of monkeys found in the tropical rain forests. Acquired through the bites of Aedes africanus and A. simpsoni which transmit the virus from the infected monkeys to man. DR (MRS) M.B. FETUGA

  3. EPIDEMIOLOGY 2 YF circulates zoonotically as three genotypes: type I and IIA in West & Central Africa, respectively and type IIB in South America. Present-day African epidemics are primarily urban. In areas where outbreaks of urban YF are common, most cases involve children because many adults are immune. Transmission in West Africa is highest during the peak of the rainy season, from July to October. DR (MRS) M.B. FETUGA

  4. TRANSMISSION • The infection is acquired by the bite of infected mosquitoes. • 1-2 weeks in the mosquito before it is capable of transmitting the virus • The virus replicates in the local LNs, enters the blood (10ry viraemia) • Then deposited in the liver, spleen, kidney, bone marrow and lymph glands. • After a short interval during which the virus persists in these organs and replicates, the virus appears in the blood again -(20ry viraemia) DR (MRS) M.B. FETUGA

  5. PATHOGENESIS 1 • Pathological changes include: • Swelling of hepatocytes followed by coagulative necrosis in the midzone of the liver lobule. • Formation of Councilman bodies (hyaline, irregular, eosinophilic masses) • Similar cellular damage occur in other organs. DR (MRS) M.B. FETUGA

  6. PATHOGENESIS 2 • KIDNEYS: Acute tubular necrosis & Renal failure. • HEART: Myocardial fiber degeneration and fatty infiltration. • BRAIN: Oedema and petechial hemorrhages. • LIVER: Direct injury results in impaired ability to carry out its functions of biosynthesis and detoxification. This is the central pathogenic event of YF. Hemorrhage is thought to result from decreased synthesis of vitamin K–dependent clotting factors and DIC. DR (MRS) M.B. FETUGA

  7. CLINICAL FEATURES1 • Incubation period 3 - 6 days. • Studies that children experience a milder disease than adults • Most cases are abortive (inapparent) and are missed. Xterised by a flu-like syndrome - fever, headache) that is easily passed as viral URTI. DR (MRS) M.B. FETUGA

  8. CLINICAL FEATURES 2 • Classic form: -Sudden onset of fever, headache, myalgia, arthralgia, anorexia, nausea, vomiting, conjunctival injection, flushing of face & neck, bradycardia and reddening of the tongue at the tip and edges with foul breath occur early in the illness. Brief period of remission occurs. DR (MRS) M.B. FETUGA

  9. CLINICAL FEATURES 3 6 – 24 hrs later: Reappearance of fever, vomiting, epigastric pain, jaundice, dehydration, GIT & other hemorrhages especially hematemesis. Albuminuria, hypotension, signs of renal failure, delirium, convulsions, and coma. Death may occur between the 7th and 10th days. Fatality rate in severe cases – close to 50%. Survivors of the acute phase of illness may succumb to renal failure or myocardial damage. DR (MRS) M.B. FETUGA

  10. LABORATORY • Viral culture • Serology: Rising titres of anti-YF antibodies • FBC: Leukopenia, thrombocytopaenia • Clotting profile: Prolonged clotting, prothrombin, and partial thromboplastin times • LFT: Hyperbilirubinemia; elevated serum transaminases; • Serum E&U: Azotaemia • Urinalysis: Albuminuria • RBS: Hypoglycemia may be present in severe cases • ECG: Bradycardia and ST-T changes. DR (MRS) M.B. FETUGA

  11. LABORATORY • Necropsy: Liver biopsy -Coagulative necrosis of hepatocytes in the midzone -Microvascular fatty degeneration -Minimal inflammation -Eosinophilic degeneration of hepatocytes (Councilman bodies –confirm the diagnosis DR (MRS) M.B. FETUGA

  12. LABORATORY • Kidneys- Acute tubular necrosis • Heart- Myocardial fibre degeneration & fatty infiltration • Brain- Oedema & petechial hemorrhage • Hematologic- DIC & ↓vit K- factors DR (MRS) M.B. FETUGA

  13. DIFFERENTIAL DIAGNOSIS • Severe malaria • Septicaemia • Hepatitis • Dengue • Marburg-Ebola • Leptospirosis DR (MRS) M.B. FETUGA

  14. MANAGEMENT • There is no specific treatment for YF. • Since patients are viraemic during the febrile phase of the illness, it is necessary to isolate YF patients e.g. using mosquito nets. • Supportive treatments include (1) Control fever thro’ tepid sponging and paracetamol (2) Vigorous IV fluid replacement of losses (3) Correct acid-base imbalance (4)Avoid drugs that are metabolized by the liver or toxic to the liver, kidney, or CNS. • Prompt correction of bleeding disorders with FRESH WHOLE BLOOD. • Dialysis for ARF. DR (MRS) M.B. FETUGA

  15. PREVENTION • YF 17D vaccine - live, attenuated vaccine. Administered as a single 0.5-mL subcutaneous injection at 9 months in the NPI schedule. (Safe) • Confers life-long immunity. • YF vaccine should not be administered to persons with symptomatic immunodeficiency diseases and those on immunosuppressants. • Small risk of encephalitis after vaccination in children younger than 9 months. DR (MRS) M.B. FETUGA

More Related