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Yellow Fever

Yellow Fever. Rob Sukumar , BIOL 402. Overview. Acute disease caused by virus Virus is within the class of flaviviruses Mosquito vector Two potential stages of the virus Effective vaccine exists. Vector ( Aedes Aegypti ). Yellow Fever has Three Transmission Cycles.

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Yellow Fever

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  1. Yellow Fever Rob Sukumar, BIOL 402

  2. Overview Acute disease caused by virus Virus is within the class of flaviviruses Mosquito vector Two potential stages of the virus Effective vaccine exists

  3. Vector (AedesAegypti)

  4. Yellow Fever has Three Transmission Cycles

  5. Initial symptoms are not severe 3-6 day incubation Acute, febrile phase Aches, nausea, shivers Average fever lasts 3.3 days

  6. Toxic Phase can follow after remission Acute phase goes into 24-hour remission 15% of patients advance to toxic phase Hepatorenal disease Excessive bleeding

  7. Liver Damage  Jaundice Yellowing of skin, eyes Caused by increased levels of bilirubin Bilirubin product of liver

  8. Virus is single-stranded, positive-sense 10 proteins (3 structural, 7 NS proteins) NS proteins responsible for replication in cells

  9. Infects Kupffer cells, hepatocytes

  10. Initial Diagnosis is Difficult Toxic phase far more obvious

  11. No Antiviral Treatment Treat symptoms

  12. Effective Vaccine Exists! Yellow fever 17D vaccine Required for certain travel

  13. There are ways to limit the risk of yellow fever Increase vaccine distribution Mosquito control

  14. Yellow Fever is a reemerging disease One of six reemerging diseases (CDC) Asia extremely vulnerable Yellow Fever Initiative (WHO,UNICEF)

  15. Sources Images http://www.lib.uiowa.edu/Hardin/md/pictures22/cdc/PHIL_2176_lores.jpg http://www.cdc.gov/ncidod/dvbid/yellowfever/images/YellowFeverWorld.jpg http://tropisme.files.wordpress.com/2009/10/aedes_aegypti_during_blood_meal.jpg http://www.mdconsult.com.libproxy.lib.unc.edu/das/article/body/195197795-2/jorg=journal&source=&sp=12238347&sid=0/N/311485/f01000160003.gif http://www.mdconsult.com.libproxy.lib.unc.edu/das/article/body/195197795-4/jorg=journal&source=&sp=12238347&sid=0/N/311485/f01000160005.gif http://www.well-women.com/images/liver3.jpg http://upload.wikimedia.org/wikipedia/commons/d/de/Jaundice_eye.jpg http://www.technion.ac.il/~mdcourse/274203/slides/Liver/8-Kupffer%20Cells%20-C.jpg http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=hcv&part=ch1 http://www.skinsight.com/images/dx/webAtlas/yellowFever_26180_lg.jpg http://www.historycooperative.org/journals/jah/94.3/images/mr06_fig01b.jpg http://static.guim.co.uk/sys-images/Guardian/Pix/pictures/2008/02/15/yellow460.jpg http://www.tarrantcounty.com/ehealth/lib/ehealth/mosquito-breeding1.jpg

  16. Sources (continued) Information Monath, Thomas. “Yellow Fever: an update.” The Lancet Infectious Diseases, 1.1. August 2001. CM Rice, EM Lenches, Eddy SR, SJ Shin, RL Sheets, JH Strauss. “Nucleotide Sequence of Yellow fever virus.” Science 229.4715 (August 1985). Robertson SE, Hull BP. “Yellow Fever: A Decade of Reemergence.” Journal of the American Medical Association 276.14. (October 9, 1996) “Yellow Fever Fact Sheet.” Weekly Epidemiological Record 85.5. (January 2009) World Health Organization. “Yellow Fever.” December, 2009. http://www.who.int/mediacentre/factsheets/fs100/en/ Center for Disease Control and Prevention. “Yellow Fever.” November, 2007. http://www.cdc.gov/ncidod/dvbid/yellowfever/ MonathTP, Barrett AD. “Pathogenesis and Pathophysiology of Yellow Fever.” Department of Microbiology, Harvard School of Public Health, 2003. Nichols EM, Gleyzer A. “Yellow Fever.” October 22, 2009. http://emedicine.medscape.com/article/787964-overview

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