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FP7 FMTXCT Project UMCE-HGUGM first year activity report Partner FIHGM

FP7 FMTXCT Project UMCE-HGUGM first year activity report Partner FIHGM. Laboratorio de Imagen M é dica. Medicina Experimental Hospital Universitario Gregorio Mara ñó n, Madrid. Workpackage 2: XCT development Workpackage 8: FMT-XCT imaging accuracy versus PET-XCT.

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FP7 FMTXCT Project UMCE-HGUGM first year activity report Partner FIHGM

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  1. FP7 FMTXCT ProjectUMCE-HGUGM first year activity report Partner FIHGM Laboratorio de Imagen Médica. Medicina Experimental Hospital Universitario Gregorio Marañón, Madrid

  2. Workpackage 2: XCT development • Workpackage 8: FMT-XCT imaging accuracy versus PET-XCT

  3. Workpackage 2: XCT development • Use of X-ray contrast agents • Double exposure techniques • Dual energy X-ray source

  4. CT System Outline Mechanical Design

  5. Multi-Energy data acquisition/processing New Tube Features

  6. Detector Dynamic Range Expansion Dual-Exposure technique • Main features • Two datasets acquired • First • Low SNR for dense materials • Detector not saturated for soft materials • Second • High SNR for dense materials • Detector saturated for soft materials • Same X-ray beam spectral properties • Different photon flux

  7. Detector Dynamic Range Expansion Dual-Exposure technique Dataset #1 Dataset #2

  8. Detector Dynamic Range Expansion Dual-Exposure technique (work in progress) Dual exposure Single exposure CNR (PTFE/Air) = 22.11 CNR (PTFE/Air) = 13.91

  9. Multi-Energy data acquisition/processing Simulated Spectra for the new tube • Changing filter setting Mean Energy = 55.6 kV Mean Energy = 66.1 kV Spectral simulations carried out using SPEKTR software libraries Siewerdsen, et.al., “Spektr: A computational tool for x-ray spectral analysis and imaging system optimization”, Med. Phys.31(9), 2004

  10. Multi-Energy data acquisition/processing Simulated Spectra for the new tube • Changing X-ray tube setting Mean Energy = 34.9 kV Mean Energy = 66.1 kV

  11. Use of X-ray contrast agents Fenestra Iopamiro

  12. Mouse 200 µA, voltage 50 kV 200 µm Fenestra LC Mouse 200 µA, voltage 50 kV 200 µm Iopamiro

  13. Mouse 200 µA, voltage 50 kV 200 µm Iopamiro Dynamic study

  14. Workpackage 8: FMT-XCT imaging accuracy versus PET-XCT

  15. Materials selection for the optical phantom construction Silicon Ti02 Pro Jet Polyester resin Bulk materials Scatterers Absorbers + + Lipid emulsions (Intralipid) Polymer microspheres India ink Water Gelatin

  16. Resolution is depth dependent Diffusion approximation: One photon mean free path ≈ 1mm Source Things to have in mind when designing a FMT phantom. Source Detector

  17. Things to have in mind when designing a FMT phantom. Heterogeneities, surface

  18. Fluorescent spheres, 2 mm (Should their size vary?) Heterogeneities 4 mm Phantom design

  19. FMT-XCT

  20. How to insert the fluorophore in the phantom? Resin vs Silicon - Mix the fluorophore with the bulk material* - Capillaries (diffusive-non diffusive interfaces) - Pellets * John Baeten et al “Development of fluorescent materials for Diffuse Fluorescence Tomography standars and phantoms” Optics express vol 15 2007

  21. What to measure Resolution. FWHM of point-like source? Quantification accuracy Sensitivity: In-vivo specific application PET phantom remarks

  22. Will the imaging performance hold in the “many body imaging situation”?

  23. PET phantom

  24. PET phantom

  25. PET phantom

  26. Detector Dynamic Range Expansion Dual-Exposure technique • Main features • X-ray tube current calculation for the second scan • Based on Histogran processing • Shift the histogram to place 75% of the total value into the High-Gain region • Dataset combination • Detector Model • Image combination based on a Maximum-Likelihood calculation assuming Independent Gaussian distribution. • i : Acquisition number • j : Pixel number • A: Current value • N: Noise value

  27. FMT system

  28. coronal Z=0.25 cm Resultados preliminares, maniquíes: Planar imaging Agar based, TiO2 (scatter), Blank ink (absorption)

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