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Growing vaccines. Present Vaccine Development. Grown in eggs Take long time to mature (up to 6 months, which gives time for the virus to undergo antigenic drift). Most often administered by way of injection Very heat sensitive, this increases transportation costs. Gm Vaccines From Plants.
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Present Vaccine Development • Grown in eggs • Take long time to mature (up to 6 months, which gives time for the virus to undergo antigenic drift). • Most often administered by way of injection • Very heat sensitive, this increases transportation costs
Gm Vaccines From Plants • Using some type of vector, either a plasmid or a virus, get the required gene into the plant embryo. • Grow a callus in a dish. • Test to see if the plant is producing the required antibodies. • Freeze dry the part of the plant which harbors the antibodies; the fruit, the leaves, or the roots.
Why Plant Vaccines?? • Plant vaccines can be administered orally, which makes them more attractive when inoculating children • They much more robust in temperature extremes than egg grown counterparts. • Could be grown up in one week, to be ready to start vaccinations. Therefore, are much more cost affective
Why not? • There is a possibility of interbreeding between the genetically modified variety of plant, and a variety which is intended for food. • This would have unknown results, and could cause the formation of a dangerous new species of plant
Present Work • Plant grown vaccines are not common presently, due to it being newer technology • Currently doing work with the bacteria that causes the bubonic plague- Y. pestis • One reason for the plague vaccine is because of fears of it’s use in bioterrorism.
