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Mass Spectrometry

What are mass spectrometers?. They are analytical tools used to measure the molecular weight of a sample.Accuracy ? 0.01 % of the total molecular weight of a large sample (biomolecule) which is enough to identify substitutions, post translational modifications.. Use to BioChemists. Accurate molecul

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Mass Spectrometry

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    1. Mass Spectrometry

    2. What are mass spectrometers? They are analytical tools used to measure the molecular weight of a sample. Accuracy – 0.01 % of the total molecular weight of a large sample (biomolecule) which is enough to identify substitutions, post translational modifications.

    3. Use to BioChemists Accurate molecular weight measurements Determine sample purity Verify amino acid substitutions, post translational modifications. Amino acids sequencing Oligonucleotide structure Protein structure determination (protein folding, macromolecular structure determination)

    4. Use in the Industry Biotechnology (Analysis of proteins, peptides, oligonucleotides) Pharmaceuticals (Drug discovery, pharmacokinetics, drug metabolism) Clinical (neonatal screening, haemoglobin analysis) Geological (Oil composition) Environmental (Water quality, food contamination)

    5. Mass Spectrometer has… 3 parts: Ionization source Analyzer Detector

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