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Intrathecal Baclofen: Increasing Patient Functionality. Mary Elizabeth S. Nelson DNP, ANP-BC Nurse Practitioner, Milwaukee, WI. A thorough evaluation is the key. Core evaluation should be a combination of subjective & objective spasticity assessments, strength and comorbid issues
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Intrathecal Baclofen: Increasing Patient Functionality Mary Elizabeth S. Nelson DNP, ANP-BC Nurse Practitioner, Milwaukee, WI.
A thorough evaluation is the key • Core evaluation should be a combination of subjective & objective spasticity assessments, strength and comorbid issues • Optional tools include Ashworth score, Tardieu scale, Spasm frequency scale, COPM, etc. • Formal PT and OT evaluations helpful • Mandatory piece is goal setting to determine spasticity impact on QOL and function
Focus on Goals • Goal is NOT the elimination of spasticity • Goal IS functional spasticity control • Goal of surgery is to place device and heal from surgery • Setting realistic expectations is key to patient satisfaction
Goals through the process • Surgery: Place device and heal from surgery • Post op: Wean oral antispasmodics while titrating dose • Maintenance: Titrate dose to BALANCE positive and negative symptoms • Optimize outcomes; consider function, position, ROM, hygiene, etc.
Dosing decisions • Standard to start at 2x trial dose unless trial dose caused loss of function due to weakness or dose lasted longer than 6-8 hours. • Adjust dose approximately 10-20% in clinic. Our max increase is 30%. • Some populations require miniscule changes (MS) and those that trial dose lasted greater than 6-8 hours • Should be able to duplicate trial response
Environmental considerations • Dosing may be different inpatient vs. outpatient • Inpatient: Controlled environment, may adjust as often as every 24 hours • Outpatient: Rely on patients assessment, may adjust weekly • Ranges: Spinal: 10 – 30%. Cerebral 5 – 15% Pediatric 5 – 15% • After 60 days label states Spinal 10 – 40% and Cerebral 5 – 20%
Flex dosing considerations • Most frequently add bolus dose when patients can identify a time of day that they suffer from increased spasticity • Conversely will decrease dose during hours patient identifies as being too weak • “One change at a time” is a good rule to follow • Will consider Flex around 200 mcg/day if patients tone not adequately controlled
Additional considerations • Idea of a bolus is to provide a “boost” of drug. Run it as quickly as possible • Advisable to start bolus dose no more than 20-30% of daily dose • If patient tolerated a 50 mcg trial dose can generally tolerate 50 mcg bolus • Best to provide too small a dose than too large and work dose up over time
Identification of problems • Implant occurred after positive response to trial dose, should be able to reproduce • Systematic work-up is best practice to identify system problems • When developing an algorithm consider plain films, side port access, dose ranges, dye studies, fluro/CT/Nuclear med access
Remember noxious stimuli • Pain • Infection • Constipation • Immobility • Incisions • Quick titration of oral antispasmodic agents • UTI • Pressure sores • Addition of SSRI, stimulants, diet medications and Betaseron • Anxiety
Don’t limit your treatment • Wean oral medications and optimize pump • If focal areas of spastic tone limit patient include botulinum toxin injections in treatment • MUST stretch and exercise a muscle that’s been loosened • PT, OT, ST, RT, Aquatic therapy, Hippo therapy • Braces, Splints, Dynamic stretch • Orthopedic surgery once spasticity treated • Treatment of noxious stimuli and underlying diseases
Additional thoughts • When patients are anesthetized spasticity is eliminated but contracture remains • If tone altered to quickly can not adjust into movement or strengthen underlying muscles quickly enough • Combination treatments may have synergistic effect • Different dosing patterns result in different responses, try delivering dose differently
Take away • Goal is to improve patients Quality of Life • Functional spasticity control! • Wean oral antispasmodics to reduce side effects • Treat noxious stimuli and concurrent issues • Stretch muscles and joints • Optimize dosing to offer the greatest benefit
Q&A time…… • Questions? • Thank you! • Mary Elizabeth S. Nelson, DNP