Meningococcal Disease

1. TMDI Tolosa Meningococcal Disease Initiative Meningococcal Disease • Presented by the Tolosa Meningococcal Disease Initative (TMDI)

2. TABLE OF CONTENTS 1.)Problem Statement / Facts 2.) Introductory Statement 3.) Work Plan 4.) Project Management/Organizational Chart 5.) Budget 6.) Potential Funder 7.) Conclusion

3. Jamie Cowey Jamie Cowey was diagnosed with meningococcal disease He Brought into to the Dr.’s office at 4pm with a purple rash, and died at 11:10 am the following day in the hospital (E. Cowey, 2011) What If? Courtney Edwards Courtney Edwards was diagnosed with meningococcal septicemia. He survived but his lower limbs and finger tips were amputated (O’Connor, 2011)

4. Problem Statement / Facts • 1.) Neisseria meningitidis is easily transferred from person to person and can cause meningococcal disease (MD). • 2.) Can cause sudden onset of fever, rashes,headaches, and can progress to overwhelming sepsis, shock, and death within hours (Ngo & Civen, 2010). • 3.) Continues to be a major cause of childhood morbidity and mortality worldwide with 1.2 million cases with 135,000 deaths worldwide (Debajeet, 2011). • 4.) Between 1998-2007 there has been a total of 2262 cases of md with 11.3% fatal cases, with the majority of cases being infants <1year of age • (Cohn, 2010). • 5.) 523 cases of md was confirmed in the Los Angeles County (LAC) between 1997-2008 with the majority of incidences being amongst children <1 year of age (Ngo & Civen, 2010).

5. Problem Statement / Facts con’t 6.) Between 1998-2007, LAC the highest mortality rate of MD, at 10.3 %was amongst person(s)>65 and <1 year of age (Ngo & Civen, 2010). 7.) The largest affected area of meningococcal disease is in Africa, with young children affected the most, in 1996 the largest outbreak of meningococcal meningitis and affected 250,000 and claimed a reported 25,000 lives (WHO). 8.) 25,000 of misdiagnosed bacterial meningitis will occur in 2008. (http://www.meningitis-spinal-bacterial.com/). 9.) Meningococcal meningitis often misdiagnosed as something less serious (http://chfs.ky.gov). 10.) In a study, it showed that infants were in the hospital for an average of 9 days versus 1 days amongst patients with md. This significantly increase hospital fees (Davis, K.L., et al., 2011). 11.) Misdiagnosis, inability to distinguish signs and symptoms, misperception of the disease, bad hygiene practices, explains the prevalence of the disease. High hospital costs are associated with the disease.

6. Introductory Statement 1.) Mission- The TMDI exists to reduce the morbidity and mortality rate of MD by educating and promoting health and wellness. 2.) History- The TMDI was formed by Nicolas Tolosa a biology graduate from the California State University Bakersfield. The TMDI is a pilot program that consists of world class experts and professionals. 3.) Affiliations- The TMDI is affiliated with the Global Meningococcal Initiative (GMI), but differ in that the TDMI focuses on the pediatric population of southern california. TMDI Tolosa Meningococcal Disease Initiative

7. Work Plan : Objectives 1.) Participants will be enrolled in and complete in a 1 hour class presentation and written quiz. 2.) Participants will participate in 1 hour lab and written lab quiz. 3.) Participants will be subjected to written final exam. 4.) Prior to enrollment subjected to pre-test. 5.) TMDI’s hypothesis.

8. Project Management / Org. Chart

9. Budget

10. Funder 1.) National Institute of Health: Eunice Kennedy Shriver National Institute of Child Health and Human Development. 2.) Main concern is the detection of potentially fatal and or disabling conditions in new borns and in children.

11. Funder continued : Summation of RFP 1.) Applications must be submitted electronically through grants.gov. 2.) Applications must use specific application forms (SF424 forms). 3.) Non-profit and private institutes of higher education can apply for grant.

12. Conclusion 1.)Meningococcal Disease still is prevalent and there is currently no vaccine for “Type B”. 2.) TMDI exists to reduce the morbidity and mortality rates of meningococcal disease by increasing awareness and knowledge of the disease. 3.) TMDI part of the Tolosa Disease Prevention Initiative (TDPI). 4.) What if?

13. Jamie Cowey Jamie Cowey was diagnosed with meningococcal disease He Brought into to the Dr.’s office at 4pm with a purple rash, and died at 11:10 am the following day in the hospital (E. Cowey, 2011) What If? Courtney Edwards Courtney Edwards was diagnosed with meningococcal septicemia. He survived but his lower limbs and finger tips were amputated (O’Connor, 2011)

14. References • Bacterial Meningitis Misdiagnosis Lawsuits.(2008). Failure to Diagnosis Bacterial • Meningitis. Retrieved from http://www.meningitis-spinal-bacterial.com/. • Cohn, A.C., et al. (2010). Changes in Neisseria meningitidis • epidemiology in the United States. Clinical Infection Diseases,15, • 184-191. • Cowey, E.(2011). Jamie Cowey. Book of Experience. Retrieved from http:// • www.meningitis.org/book-of-experience/jamie-cowey-25158. • Davis, K.L., et. al. 2011. Hospital costs, length of stay and mortality associated with • childhood, adolescent and young adult meningicoccal disease in the US. Applied Health Economics and Health Policy, 9,197-207. • Debajeet, C., et al. (2011). An evaluation of emerging vaccines for • childhood meningococcal disease. BMC Public Health,11,29. • Ngo, V. & R. Civen (2010). Meningococcal disease trends in Los • Angeles County, 1995-2008. Acute Communicable Disease Control 2010 Special Studies Report,15-20. • O’Connor, E.(2011). Courtney Edwards. Book of Experience. Retrieved from http:// • www.meningitis.org/book-of-experience/jamie-cowey-25158.

15. References • World Health Organization.(2011). Meningococcal meningitis Fact sheet. • Retrieved from http://www.emro.who.int/sudan/pdf/FactSheet-Meningitis.pdf • All images retrieved from www.google.com/images & www.meningitis.org