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Varicella-zoster

Varicella-zoster. The disease and Panbio product training. Overview. Caused by Varicella zoster virus Chicken pox highly contagious most commonly affects children Shingles (Herpes zoster) mainly a disease of adults, esp. elderly reactivation of virus. Infectious a gent & epidemiology.

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Varicella-zoster

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  1. Varicella-zoster The disease and Panbio product training

  2. Overview • Caused by Varicella zoster virus • Chicken pox • highly contagious • most commonly affects children • Shingles (Herpes zoster) • mainly a disease of adults, esp. elderly • reactivation of virus

  3. Infectious agent & epidemiology • Varicella-zoster virus • member of the Herpesvirus group • Occurrence • worldwide • Reservoir • humans are the only host

  4. Clinical notes • Chicken pox symptoms • fever, more severe in adults • skin eruption(abundant of parts of body normally covered) • headache • abdominal pains • most common complications include bacterial infection of skin legions

  5. Clinical notes cont. • Shingles • vesicles appear on skin areas supplied by sensory nerves • spread of vesicles is typically unilateral • sever pain and paresthesia is common • elderly may experience neuralgia • immunocompromised persons may be more susceptible • complications include pneumonia, encephalitis & Reyes Syndrome

  6. Clinical notes cont. • Mode of Transmission • person to person contact, droplet or airborne spread of respiratory secretions • Incubation Period • 2 to 3 weeks • Treatment • Acyclovir, Vidarabine

  7. Antibody response • Specific antibodies detectable by 3rd day of rash • IgM antibodies decline to undetectable levels within 2-3 months • Children with immunosuppressive disorders may not produce IgG

  8. Diagnosis • Usually made from clinical symptoms • Isolation of the virus in cell culture • Direct fluorescence antibody (DFA) • Indirect Immunofluorescence • Complement fixation • Neutralisation • ELISA • detection of specific IgG and IgM antibodies • considered the most specific with comparable sensitivity to other methods

  9. Panbio VZV ELISAs • Varicella Zoster IgG Cat # E-VZV01G • 100% sensitivity & specificity • Varicella Zoster IgM Cat # E-VZV01M • Ideal for laboratory use • 1hr 10min assay time • IgG and IgM kits available • Indirect ELISA format

  10. Panbio VZV IFA • VZV IgG IFA kit Cat# I-VZV01G • VZV IgM IFA kit Cat# I-VZV01M • VZV IFA slides Cat# I-VZV01X

  11. Promotional resources • Clinical Sheet • IgG Technical Sheet • Publications • General • Overhead transparencies

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