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Malaria Medicines and Diagnostics

Malaria Medicines and Diagnostics. WHO/UNICEF Technical Briefing Seminar on Essential Medicines Policies 30 October 2012, WHO Headquarters, Geneva - Salle A. A. Bosman, MD PhD Coordinator, Diagnosis Treatment and Vaccines. Malaria positivity rate in African health facilities.

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Malaria Medicines and Diagnostics

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  1. Malaria Medicines and Diagnostics WHO/UNICEF Technical Briefing Seminar on Essential Medicines Policies 30 October 2012, WHO Headquarters, Geneva - Salle A A. Bosman, MD PhD Coordinator, Diagnosis Treatment and Vaccines

  2. Malaria positivity rate in African health facilities 39 studies conducted between 1986 and 2007 in 16 African countries <year 2000 >year 2000 100 90 7686 5372 7785 2118 700 2376 80 70 60 56% 50% 50 PR (%) 40 31% 30 27% 20% 20 13% 10 0 <5y >15y <5y >15y 5-15y 5-15y Age groups Age groups D’Acremont et al, Malaria J 2010

  3. Interactions in malaria between medicines, diagnostics and vector control LLIN/IRS - - - - RDT Severe malaria treatment ACT + - Medicines for NMFI non-ACTs + Product interactions more complex in private sector (order of entry, perseverance etc.)

  4. ACT Deployment of RDTs in Livingstone (Zambia): impact on malaria cases and ACT consumption RDTs ACTs From over 25'000 ACTs in 2007 to less than 5'000 in 2008 Source: NMCC, Zambia MoH

  5. The example of Senegal: ~ 0.5 million less ACT consumed in 2008-2009 Suspected cases Tested cases Positive cases Treated cases World malaria report 2010

  6. ACT procurement with international funds data provided by 8 companies eligible for procurement by WHO/UNICEF

  7. RDT performance in Phase 2 ofRounds 1 – 3against wild type (clinical) samples containing P. falciparum at low (200 parasites/μl) and high (2000 or 5000 parasites/μl) parasite densities and clean-negative samples PDS at 2000 parasites/μl PDS at 200 parasites/μl Invalid Rate False Positive Rate

  8. Malaria RDT sales Sales by panel detection score (PDS) Sales to public and private sectors

  9. RDT Product Testing: Rounds 1 - 4

  10. T3 – Test. Treat. Track.Scaling up diagnostic testing, treatment and surveillance Infographic disponible: http://www.youtube.com/watch?v=vnsoTPE_PUc&feature=youtu.be

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