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In The Name Of God. Cornea and Anterior Segment. MR SHOJA. MD Shahid sadoughi Medical School. TEACHING SET NO.4 PREVENTION OFCHILDHOOD BLINDNESS. INTERNATIONAL CENTRE FOR EYE HEALTH. . Causes of Childhood Blindness. Cloudy Cornea in infancy. Gonococcal keratitis.
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Cornea and Anterior Segment MR SHOJA.MD Shahid sadoughi Medical School
TEACHING SET NO.4 PREVENTION OFCHILDHOOD BLINDNESS INTERNATIONAL CENTRE FOR EYE HEALTH . Causes of Childhood Blindness
Cloudy Cornea in infancy Gonococcal keratitis. Congenital Corneal Diseases. Obstetrical Forceps Trauma. Congenital Gluacoma.
Sclero Cornea Corneal Dermoid Aniridia Congenital Rubella
CYSTINOSIS KAYSER FLEISHER RING
Congenital Hereditary Endothelial Dystrophy (CHED) Endothelial dysfunction . Increased cornea thickness. Cornea is edematous & bluish. IOP is normal . Primary treatment iskeratoplasty
Macro Cornea 13 mm horizontal diameter X-linked reccessive pattern 90% patients are male No Cornea clouding , photophobia Microcornea
Keratoglobus Cornea is thinner Deep anterior chamber Spontaneous break in descemet,s M Cornea easily ruptured by truma. Part of Ehlers-Danols type 6 syndrome Paitient should wear protective lens.
Keratoconus Bilateral , twice in female Central , paracentral thining. Irregular myopic astigmatism. Chronic eye rubbing is a factor VKC is a risk factor . Common in Down ,Osteogenesis imperfecta Rapid progression occur in teanager
Acute keratoconus (Hydrops) Common in Down, s syndrome Result from ocular message Often at night,extremely painful Rupture in Descemet,s membrane Deep opacity at apex of cone If hydrops happens, don’t lose heart
Cloboma of Iris Occur in inferonasal Iris. Microphthalmia is common. Cloboma of retina & choroid . VA ranges is low.
Stromal Dystrophies Granular Macular Lattice
Primary Congenital Glaucoma Incidence in USA is 1:10000 Incidence in Saudia Arabic is 1:2500 75% have bilateral involvement Occurs in 65% of male ,reccessive pattern 60% occur before 6 months 80% by 1 year of age
TEACHING SET NO.4 PREVENTION OFCHILDHOOD BLINDNESS INTERNATIONAL CENTRE FOR EYE HEALTH Congenital Glaucoma
Clinical Triad 1-Epiphora 2 - Photophobia 3 – Blepharospasm
Signs: • Elevated IOP • Cloudy corneal • Buphthalmos • Optic nerve cupping • Descemet,s membrane tear • Increased axial length blunt trauma . hyphema Rupture of globe
Congenital Glaucoma. All infants with cloudy corneas must be evaluated for Congenital Glaucoma . • General practitioners especially obstetricians and paediatricians should know importance of early referral and intervention of congenital glaucoma. • Sporadic but mutation found in the CYPIBI gene on chromosome 2 p 21.
Systemic conditions with Glaucoma Aniridia Retinopathy of prematurity Neuro fibromatosis Sturge weber syndrome Congenital Rubella
CongenitalRubella Syndrome Invasion of lens by virus ( first trimister) Dense bilateralnuclearCataract PDA,deafness & mental retardation Immature & poorly dilated Iris ,Microcornea. 1/3 hazy cornea due to Keratitis & Glaucoma Elevated infant IgM antibody against rubella. Extreme inflammation post-op Complete removal of lens material.
Treatment Poor if present at birth Poor if corneal diameter is> 14 mm 50% becomes legally blind favourable prognositic group onset 3-12 months Amblyopia is major problems Treatment is not sought until considerable damage has already occurred.
How Is Glaucoma Treated? • Medications • Prostaglandin analogs • Beta blockers • Alpha agonists • Carbonic anhydrase inhibitors • Cholinergic agents • Laser therapy • Surgery
Causes of Visual Loss in Congenital Glaucoma Optic never damage Corneal opacities Corneal astigmatism Surface irregularitis Amblyopia
Differential Diagnosisof Congenital Glaucoma Axial myopia primary megalocornea CORNEAL FINDINGS slerocornea congenital hereditary endothelial dystrophy Keratitis cystinosis birth trauma EPIPHORA Nasolacrimal duct obstruction
Bacterial keratitis
Clinical presentation Rapid onset of pain Conjunctival injection (Redness) Photophobia Decreased vision Discharge and lid edema
Ocular infections
Corneal Diameters Axial Length (mm) Age Normal Possible Glaucoma normal Glaucoma Newborns9.5-10.5 11.5-12.5 16-17 >20 1year 10-11.5 12.0-12.5 20.1 >22.5 2year 11.5-12 12.5-13.0 21.3 >23 Corneal Dismeters and Axial Lengths for Glaucoma
Complete Ocular Examination Slit lamp Exam Retinoscopy Gonioscopy Tonometry Measurment of corneal diameter Optic Never evaluation Follow -up Evaluation (4-6 weeks)