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Virus-Induced Immunopathology

Cell mediated immunopathology. Contact between CTL (CD8 ) and targetTCR recognizes cognate peptide presented by MHC IActivation of CTL; release of membrane granules with perforin and granzymePerforin: Pore formation in target cells resuting in cytolysisGranzyme B: induction of apoptosisRelease

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Virus-Induced Immunopathology

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    1. Virus-Induced Immunopathology Cell mediated Immunopathology Antibody-mediated Immunopathology Virus-initiated Immunopathology

    2. Cell mediated immunopathology Contact between CTL (CD8+) and target TCR recognizes cognate peptide presented by MHC I Activation of CTL; release of membrane granules with perforin and granzyme Perforin: Pore formation in target cells resuting in cytolysis Granzyme B: induction of apoptosis Release of Inflammatory cytokines (TNF-a, IFN-g, ILs) CD4+ T cells can enhance CD8-mediated immunopathology NK Cell Non-specific of “non-self” ADCC

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