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Antiarrhythmic drugs an overview

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Antiarrhythmic drugs an overview

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    1. Antiarrhythmic drugs… an overview Peter Light Assistant Professor Dept of Pharmacology

    2. Arrhythmias Disturbances in ionic homeostasis can trigger arrhythmias May be caused by genetic defects, ischemia, drugs and hormones Ion channels control ionic balance and are therefore good targets for antiarrhythmic drugs

    3. What is an arrhythmia?

    4. Arrhythmias

    5. Treating arrhythmias…. Surgical intervention Implantable pacemakers and defibrillators Drugs

    6. Ion Flow and the Action Potential

    10. Vaughan-Williams Classification Of Anti-arrhythmic Drugs

    11. Class 1 Anti-arrhythmics

    12. Class 1A Typical example: - Quinidine

    13. Class 1B Typical example: Lidocaine

    14. Use dependence

    15. Class 1B Typical example: Lidocaine

    16. CLASS IC Anti-arrhythmics

    17. CLASS II Anti-arrhythmics

    18. CLASS III Anti-arrhythmics

    19. CLASS III Anti-arrhythmics

    21. Drugs: Long QT and TdP

    22. Drugs: LQT and TdP

    23. Drugs that prolong QT..

    24. Drugs that prolong QT..cont

    25. Seldane Seldane (terfenadine), an anti-histamine OTC hay fever drug was withdrawn from market in 1997.

    26. CLASS 4 Anti-arrhythmics Eg.Verapamil and Diltiazem

    27. Other clinically important anti-arrhythmics.

    29. Cardiac Glycosides (digitalis glycosides eg.. Digoxin)

    30. Toxicity of glycosides

    31. Glycosides and afterdepolarizations

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