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Production of tin-117m with high specific activity by recoil

This paper explores the production of the radionuclide 117mSn with high specific activity through the recoil method. The aim is to achieve a higher signal-to-mass ratio, reduce chemical toxicity, and optimize therapeutic effects.

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Production of tin-117m with high specific activity by recoil

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  1. Production of tin-117m with high specific activity by recoil By Kefilwe Thoane North west university Energy Postgraduate Conference 2013

  2. Contents • Introduction • Aim • Method • Results and discussion • Conclusion • Reference

  3. Introduction • The radionuclide 117mSn can be produced in a nuclear reactor or an accelerator. • 117mSn has a half-life of 13,60 days and gamma energy of 159 KeV (86%). • The radionuclide emits low energy conversion electrons with intensities of 127 keV (65%), 129 keV (12%) and 152 keV (26%).

  4. Aim • Obtain 117mSn with high specific activity (Ci/g) • Adapting Szilard-Chalmers reaction. The high specific activity means • Higher signal to mass • Less chemical toxicity • Administer less but still have sufficient therapeutic effect.

  5. Method

  6. Method conti... • Targets were weighed accurately and irradiated for 24 hours. • Radiochemical separation was performed using sulphuric acid and nitric acid as aqua regia. ICP analysis • Activated carbon • Graphite • Tin oxide • Specific activity = Amount of activity/ mass

  7. Results

  8. Discussion • Four recoil capture media used. • Graphite flake pellet > graphite flake powder > graphite> activated carbon granules. The graphite flake pellet is the best recoil capture medium because of the physical properties graphite possess. • Layers make it possible to trap recoil atoms. • Occurs as isolated, flat, plate like particles, hexagonal.

  9. Conclusion • The radionuclide 117mSn was captured by the recoil medium during the irradiation process. • Future work will be to optimise the conditions with the best recoil capture medium, namely graphite flake pellets.

  10. Reference • Kyu, K. D., Abramov, A. A., Volkova, S.V., Dubovaya, D. V., Lofa, B. Z., Seropegina , E. N.1999. Extraction of tin-117m from antimonic target irradiated by protons. • Srivastava, S.C., The role of electron-emitting radiopharmaceuticals in the palliative treatment of metastatic bone palliation for radiosynovectomy: applications of conversion electron emitter tin-117m 2007. Braz. arch. Boil. Bechno; 50: 49-72. • Jansen, D.R. An in vitro approach to evaluate and develop potential 117mSn based bone-seeking radiopharmaceuticals. 2010., Dissertation. Delft University of technology.

  11. Acknowledgements • Prof Jan Rijn Zeevaart • Dr David Jansen • Dr Hester Oosthuizen • Financial support • Necsa • National Research Foundation (NRF) of South Africa

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