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Biomimetic Surfaces for Manipulation and Targeting Of Bacteria and / or Mammalian Cells

Biomimetic Surfaces for Manipulation and Targeting Of Bacteria and / or Mammalian Cells (in Flow) . Maria Santore Polymer Science and Engineering Umass Amherst. Cell surface. Cell surface. Non-biological adhesion elements Robust, low cost

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Biomimetic Surfaces for Manipulation and Targeting Of Bacteria and / or Mammalian Cells

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  1. Biomimetic Surfaces for Manipulation and Targeting Of Bacteria and / or Mammalian Cells (in Flow) Maria Santore Polymer Science and Engineering Umass Amherst Cell surface Cell surface • Non-biological adhesion elements Robust, low cost • Highly selective multivalent binding of targets • Coupling of surface chemistry effects and flow • Re-usable, non-protein fouling, (implantable?) Adhesion element Polymer brush collector Santore, santore@mail.pse.umass.edu

  2. Translational Potential Protein separations Enrich / Discriminate Cancer Cells Bacteria Discrimination Harvest Auto-Immune Tcells Capture Stem Cells from Blood Selective Bacterial Killing? Mammalian Cell Reprogramming?

  3. Opportunities for Collaboration Direct dynamic delivery to cells Protein separations development-ready Particular challenges for cell capture or bacterial discrimination Blood, breastmilk, other fluids…

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