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HIFU mediated drug delivery: Vascular shutdown facilitates drug depot effect

HIFU mediated drug delivery: Vascular shutdown facilitates drug depot effect. Gasselhuber A. 1 , Appanaboyina S. 1 , Dreher M.R. 2 , Wood B.J. 2 , Haemmerich D. 1 1 Dept. Pediatrics, Medical Univ. of South Carolina 2 Center for Interventional Oncology, National Cancer Institute. Disclosures.

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HIFU mediated drug delivery: Vascular shutdown facilitates drug depot effect

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  1. HIFU mediated drug delivery: Vascular shutdown facilitates drug depot effect Gasselhuber A.1, Appanaboyina S. 1, Dreher M.R.2, Wood B.J.2, Haemmerich D.1 1Dept. Pediatrics, Medical Univ. of South Carolina 2Center for Interventional Oncology, National Cancer Institute

  2. Disclosures • none

  3. Low-Temperature Sensitive Liposomes (LTSL) Drug release (Doxorubicin) at hyperthermic temperatures Doxorubicin Release from LTSL(from Gasselhuber et al., Int J Hyperthermia 2010)

  4. HIFU-mediated targeted drug delivery From Staruch et al., Int J Hyperthermia 2011

  5. Study Goal • Computer Simulation of HIFU+LTSL drug delivery • Heat transfer model • Drug Delivery Model • Two heating scenarios: • 7 min hyperthermia (42 ºC) • 7 min hyperthermia + brief ablation pulse(to shut down blood flow)

  6. Computer Model:HIFU + LTSL Tissue Temperature LTSL Release IntravascularSpace Perfusion Tissue Heat-Transfer Model Pharmacokinetic Model

  7. Mathematical Drug Delivery Model Drug delivery from LTSL in tumor(see also Gasselhuber et al., Int J Hyperthermia 2010)

  8. Hyperthermia vs. HT+Ablation HT+Ablation Hyperthermia Temperature Perfusion

  9. HT+Ablation Hyperthermia

  10. Drug Concentrations: HT + Ablation HIFU HIFU+Ablation

  11. Summary • Elimination of blood flow by brief high-temperature heating pulse considerably increases tissue drug uptake • Depot Effect • Other blood flow reducing methods (embolization) would have similar effect

  12. Questions? Charleston, SC ABLATION. MUSC.EDU Funding: NIH R01CA118990, R21 CA135519

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