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Cytotoxicity and Uptake of Nanoparticles in Cells

Cytotoxicity and Uptake of Nanoparticles in Cells. Courtney Rister Faculty Advisors: Virginia Ferguson Conrad Stoldt Department of Mechanical Engineering University of Colorado, Boulder. Objective. How does nanoparticle presence affect cellular function and behavior?

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Cytotoxicity and Uptake of Nanoparticles in Cells

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  1. Cytotoxicity and Uptake of Nanoparticles in Cells Courtney Rister Faculty Advisors: Virginia Ferguson Conrad Stoldt Department of Mechanical Engineering University of Colorado, Boulder

  2. Objective • How does nanoparticle presence affect cellular function and behavior? • Little is known on how they interconnect with cytoskeleton • Long term goals • Which nanoparticles are most efficient? • What is the best way to deliver the nanoparticles? Introduction to Research Presentation

  3. Background • Uses of magnetic nanoparticles in bioengineering • Therapeutic • Hyperthermia • Drug Delivery • Diagnostic • Nuclear Magnetic Resonance (NMR) Introduction to Research Presentation

  4. Methodology • Perform cell cultures with Mammalian SaOS-2 cells • Obtain either Magnetite or Gadolinium nanoparticle cells • Encapsulate nanoparticles in liposomes • Prevents formation of large aggregates and increases biocompatibility • Introduce nanoparticles to SaOS-2 cells and record effect Introduction to Research Presentation

  5. Requirements • TEM (Transmission Electron Microscope) • BioServe equipment & supplies • Cells • Culture media and facilities Introduction to Research Presentation

  6. Timeline Introduction to Research Presentation

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