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Cell-Mediated Cytotoxicity. Cytotoxic T-Lymphocytes Natural Killer Cells Antibody-Dependent, Cell-mediated Cytotoxicity Delayed-type Hypersensitivity. Folder Title: CellKill. Updated: November, 25, 2004. KillTitl.
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Cell-Mediated Cytotoxicity Cytotoxic T-Lymphocytes Natural Killer Cells Antibody-Dependent, Cell-mediated Cytotoxicity Delayed-type Hypersensitivity Folder Title: CellKill Updated: November, 25, 2004 KillTitl
Cell-Mediated Immunity (CMI):Passive transfer from donor to recipient of cells alone, transfers the immune response function Response to: Neoplastic (cancer) Cells Infected or Altered Cells Intra-cellular Pathogens Fungi Allo-grafts and other transplants CMIRoles
Cell-Mediated Immunity (CMI):Types of Cytotoxic Cells Antigen-Specific T-Cells (Have TCR): Tc : Cytotoxic T-Cells TDTH : Delayed-Type Hypersensitivity Cells ("Type IV Hypersensitivity") Non-Antigen-Specific Cells: Macrophages NK Cells Granulocytes: Neutrophils, Eosinophils, Basophils and Tissue Mast Cells CMICells
Cytotoxic T-Cell Binding to Target Cell (figure 16-6, Kuby, 3rd Edition) CTL binding to Target Cell TC = Target Cell for Cytolytic T-Cell Smaller Cell = CTL CTLandTC
T-Cell Killing by Induction of Apoptosis(figure 16-8, Kuby, 3rd Edition) Signals Activation of Apoptosis ICE = Interleukin 1 Converting Enzyme CTL&Apop
Natural Killer Cell Targets and Restriction to Altered-Self(Figure 16-11, Kuby, 3rd Edition) No Killing (Recognized Self; MHC Class I) Target Cell Killed (Did not recognize self; low MHC Class I NKTarget