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Division of Genetic and Reproductive Toxicology

Division of Genetic and Reproductive Toxicology. Staff Research Focus Areas Senior Investigators Framework for Research. DGRT Staff. 31.8 FTE Government positions 14 Research Scientists 3 Staff Fellows 12.8 Support Scientists 2 Administrative 6 ORISE Post Docs

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Division of Genetic and Reproductive Toxicology

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  1. Division of Genetic and Reproductive Toxicology • Staff • Research Focus Areas • Senior Investigators • Framework for Research

  2. DGRT Staff • 31.8 FTE Government positions • 14 Research Scientists • 3 Staff Fellows • 12.8 Support Scientists • 2 Administrative • 6 ORISE Post Docs • 1 ORISE Pre Doc

  3. DGRT Research Focus Areas Diet and Nutrition Genetic Toxicology Reproductive/ Developmental Toxicology Genomics & Proteomics

  4. Senior Investigators--Genetic Toxicology In vivo: Bob Heflich Ben Aidoo Tao Chen* Vasily Dobrovolsky* Jim Fuscoe Magomed Khaidakov** Manju Manjanatha Page McKinzie** Suzanne Morris Barbara Parsons* Carrie Valentine In vitro: Suzanne Morris Tao Chen* Bruce Hass TBN** * Staff Fellow ** Post Doc

  5. Senior Investigators--Reproductive/DevelopmentalToxicology Deb Hansen Bill Branham Ming Lu Dan Sheehan

  6. Senior Investigators--Diet and Nutrition Ritchie Feuers Peter Duffy Varsha Desai** Ming Lu Ben Aidoo Deb Hansen Bob Heflich Sachin Bendre*** Suzanne Morris ** Post Doc ***Pre Doc

  7. Senior Investigators--Genomics and proteomics Jim Fuscoe Ritchie Feuers Angela Harris Varsha Desai** Suzanne Morris ** Post Doc

  8. Framework for DGRT Research CDER CBER CVM CFSAN CDRH Basic Applied Research to Improve Regulatory Decision Making (Risk Assessment) OWH Chemical Specific Information

  9. Framework for DGRT Research Basic Applied Research to Improve Regulatory Decision Making (Risk Assessment) --Hazard Characterization --Dose Response Assessment

  10. Framework for DGRT Research Hazard Characterization --Develop new methods --Characterize/understand assays --Interpretation of data --Modes of action for toxicants --Rodent/human extrapolation --Develop guidelines

  11. Framework for DGRT Research Hazard Characterization --Develop new methods PhiX174 Gene Mutation Keratinocyte hprt TK+/- Mouse Model MutEx/ACB-PCR Genotypic Selection Endocrine Knowledge FluorescentMarkers

  12. Framework for DGRT Research Hazard Characterization --Characterize/understand assays --Interpretation of data In Vivo Mouse TK Assay In Vivo lacI and hprt Human Lymphoblastoid TK Assay Filter Arrays Mouse Lymphoma TK Assay

  13. Framework for DGRT Research Hazard Characterization --Modes of action for toxicants DNA Sequence Analysis Folate & Neural Tube Development Chromosomal Mutations Genomic Rearrangements Impact of Dietary Restriction on Somatic Mutation and Physiological Parameters Gene Expression & Protein Production

  14. Framework for DGRT Research Hazard Characterization --Rodent/human extrapolation Response of Hepatocytes to Toxicants Response to Dietary Restriction & Nutritional Changes

  15. Framework for DGRT Research Hazard Characterization --Develop guidelines Mouse Lymphoma TK Assay In Vivo Gene Mutation Assays

  16. Framework for DGRT Research Dose Response Assessment --Relevant doses --Susceptibility/variability --Rodent/human extrapolation --Cancer/noncancer --Quantitative models

  17. Framework for DGRT Research Dose Response Assessment --Relevant doses Dose Selection Genomics/Proteomics Biomarkers

  18. Framework for DGRT Research Dose Response Assessment --Susceptibility/variability Fetus/Newborn/ Young Child Diet: Antioxidants Dietary Restriction Phytoestrogens Repair Deficiency: PMS2-Mismatch Mice

  19. Framework for DGRT Research Dose Response Assessment --Rodent/human extrapolation Liver Toxicity Biomarkers Diet and Nutrition Genomics/Proteomics

  20. Framework for DGRT Research Dose Response Assessment --Cancer/noncancer --Quantitative models Mechanistic Commonality Genomics/Proteomics

  21. Framework for DGRT Research --Genistein --Coumestrol --Leucomalachite Green --AZT --UV light/Phototoxicity Chemical Specific Information

  22. Cross Agency Collaboration DBT DGRT DBRA DNT CDER OWH CFSAN NIEHS ACADEMIA EPA NTP

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