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Division of Genetic and Reproductive Toxicology. Staff Research Focus Areas Senior Investigators Framework for Research. DGRT Staff. 31.8 FTE Government positions 14 Research Scientists 3 Staff Fellows 12.8 Support Scientists 2 Administrative 6 ORISE Post Docs
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Division of Genetic and Reproductive Toxicology • Staff • Research Focus Areas • Senior Investigators • Framework for Research
DGRT Staff • 31.8 FTE Government positions • 14 Research Scientists • 3 Staff Fellows • 12.8 Support Scientists • 2 Administrative • 6 ORISE Post Docs • 1 ORISE Pre Doc
DGRT Research Focus Areas Diet and Nutrition Genetic Toxicology Reproductive/ Developmental Toxicology Genomics & Proteomics
Senior Investigators--Genetic Toxicology In vivo: Bob Heflich Ben Aidoo Tao Chen* Vasily Dobrovolsky* Jim Fuscoe Magomed Khaidakov** Manju Manjanatha Page McKinzie** Suzanne Morris Barbara Parsons* Carrie Valentine In vitro: Suzanne Morris Tao Chen* Bruce Hass TBN** * Staff Fellow ** Post Doc
Senior Investigators--Reproductive/DevelopmentalToxicology Deb Hansen Bill Branham Ming Lu Dan Sheehan
Senior Investigators--Diet and Nutrition Ritchie Feuers Peter Duffy Varsha Desai** Ming Lu Ben Aidoo Deb Hansen Bob Heflich Sachin Bendre*** Suzanne Morris ** Post Doc ***Pre Doc
Senior Investigators--Genomics and proteomics Jim Fuscoe Ritchie Feuers Angela Harris Varsha Desai** Suzanne Morris ** Post Doc
Framework for DGRT Research CDER CBER CVM CFSAN CDRH Basic Applied Research to Improve Regulatory Decision Making (Risk Assessment) OWH Chemical Specific Information
Framework for DGRT Research Basic Applied Research to Improve Regulatory Decision Making (Risk Assessment) --Hazard Characterization --Dose Response Assessment
Framework for DGRT Research Hazard Characterization --Develop new methods --Characterize/understand assays --Interpretation of data --Modes of action for toxicants --Rodent/human extrapolation --Develop guidelines
Framework for DGRT Research Hazard Characterization --Develop new methods PhiX174 Gene Mutation Keratinocyte hprt TK+/- Mouse Model MutEx/ACB-PCR Genotypic Selection Endocrine Knowledge FluorescentMarkers
Framework for DGRT Research Hazard Characterization --Characterize/understand assays --Interpretation of data In Vivo Mouse TK Assay In Vivo lacI and hprt Human Lymphoblastoid TK Assay Filter Arrays Mouse Lymphoma TK Assay
Framework for DGRT Research Hazard Characterization --Modes of action for toxicants DNA Sequence Analysis Folate & Neural Tube Development Chromosomal Mutations Genomic Rearrangements Impact of Dietary Restriction on Somatic Mutation and Physiological Parameters Gene Expression & Protein Production
Framework for DGRT Research Hazard Characterization --Rodent/human extrapolation Response of Hepatocytes to Toxicants Response to Dietary Restriction & Nutritional Changes
Framework for DGRT Research Hazard Characterization --Develop guidelines Mouse Lymphoma TK Assay In Vivo Gene Mutation Assays
Framework for DGRT Research Dose Response Assessment --Relevant doses --Susceptibility/variability --Rodent/human extrapolation --Cancer/noncancer --Quantitative models
Framework for DGRT Research Dose Response Assessment --Relevant doses Dose Selection Genomics/Proteomics Biomarkers
Framework for DGRT Research Dose Response Assessment --Susceptibility/variability Fetus/Newborn/ Young Child Diet: Antioxidants Dietary Restriction Phytoestrogens Repair Deficiency: PMS2-Mismatch Mice
Framework for DGRT Research Dose Response Assessment --Rodent/human extrapolation Liver Toxicity Biomarkers Diet and Nutrition Genomics/Proteomics
Framework for DGRT Research Dose Response Assessment --Cancer/noncancer --Quantitative models Mechanistic Commonality Genomics/Proteomics
Framework for DGRT Research --Genistein --Coumestrol --Leucomalachite Green --AZT --UV light/Phototoxicity Chemical Specific Information
Cross Agency Collaboration DBT DGRT DBRA DNT CDER OWH CFSAN NIEHS ACADEMIA EPA NTP