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Skin and relative connective tissue

Skin and relative connective tissue. SYLLABUS: RBP( Robbins Basic Pathology ) Chapter : The Skin. Skin and relative connective tissue. Dermatofibroma Pilomatrixoma Basal cell carcinoma Melanocytic nevus 323 Seborrheic keratosis. Dermatofibroma. fibroblast-like spindle cells

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Skin and relative connective tissue

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  1. Skin and relative connective tissue SYLLABUS: RBP(Robbins Basic Pathology) Chapter: TheSkin

  2. Skin and relative connective tissue • Dermatofibroma • Pilomatrixoma • Basal cell carcinoma • Melanocytic nevus 323Seborrheic keratosis

  3. Dermatofibroma • fibroblast-like spindle cells • histiocytes • small blood vessels • overlying epidermis with elongated rete ridges and with increased basal melanin (dirty fingers)

  4. Dermatofibroma

  5. Dermatofibroma

  6. Pilomatrixoma • uniform small basaloid cells at periphery • large squamous cells with gradual loss of nuclei (shadow cells) (older lesions show less basaloid cells and more shadow cells) • often associated granulomatous inflammation and calcification

  7. Pilomatrixoma

  8. Pilomatrixoma

  9. Basal cell carcinoma • neoplastic cells similar to basal layer of epidermis, basophilic with high nuclear/cytoplasmic ratio • nests typically have marked peripheral palisading • prominent fibroblastic stroma arranged around tumor lobules

  10. Basal cell carcinoma

  11. Basal cell carcinoma

  12. Melanocytic nevus • nests of cohesive melanocytes, which are generally cuboidal and occasionally spindled, with inconspicuous nucleolus, variable melanin • individual melanocytes do not extend beyond nests at lateral margins • nests of similar size with rounded, sharp borders • little to no inflammation

  13. Melanocytic nevus

  14. Melanocytic nevus

  15. Seborrheic keratosis • acanthosis, hyperkeratosis, and papillomatosis • well-circumscribed proliferation of basaloid cells completely replacing normal epidermis with horn pseudocysts • no dermal invasion • no mitoses, necrosis, ductal structures, or peripheral palisading • basal melanin common

  16. Seborrheic keratosis

  17. Seborrheic keratosis

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