1 / 7

One-Gene-One-Enzyme, Pseudogenes & Common Ancestry

One-Gene-One-Enzyme, Pseudogenes & Common Ancestry. The following animation is intended to show: The one-gene-one-enzyme hypothesis

gil
Download Presentation

One-Gene-One-Enzyme, Pseudogenes & Common Ancestry

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. One-Gene-One-Enzyme,Pseudogenes& Common Ancestry The following animation is intended to show: • The one-gene-one-enzyme hypothesis • How a mutation in one gene (probably in some early pre-primate) prevented the production of Vitamin C, explaining why all primates today require Vitamin C in their diets (not so with other mammals). • The GULO pseudogene evidence for the common ancestry of primates.

  2. What’s a Pseudogene? A pseudogene is a DNA sequence that is nearly identical to that of a functional gene, but contains one or more mutations, making it non-functional. Much of the intron material in the genomes of organisms is composed of recognizable pseudogenes.

  3. GULO gene Gene 3 Gene 2 Gulo Enz Enzyme 3 Enzyme 2 Pseudogenes and Vitamin C In most mammals Gene 1 Not so in primates… Enzyme 1 A B C Vitamin C D Vitamin C Portion of Working GULO Gene in Rat: Note Deletion Matching GULO Pseudogenes in 4 Primates

  4. Analysis • Any one of thousands of possible mutations in the several genes for a biochemical pathway could explain why a particular species fails to make a particular enzyme. • What does this suggest about the fact that Vitamin C production is blocked in several similar species by the exact same mutation in the Gulo gene? • Maybe common ancestry?

  5. Vitamin C, GULO Pseudogenes & Primate Evolution

  6. Note Simplification Three adjacent DNA segments (genes) were shown as necessary for Vitamin C to be formed. In reality, there can be more genes (or fewer), and they may not be adjacent, or even in the same chromosome.

  7. Pseudogenes: Vitamin C& Common Ancestry Part C of a 3-part suite on Pseudogenesand Evolution By Mary Ball and Steve Karr Carson-Newman College Posted on the ENSI website Animation by Larry FlammerENSI webmaster

More Related