The Next Generation of Health Care, Personalized Wellness and Prevention

1. The Next Generation of Health Care, Personalized Wellness and Prevention

2. The Power of “Knowing” Palm Reader Tarot Card Reader PersonalizedGenomics Shaman Horoscope HRA History Now Scientific Breakthrough

3. Have you ever wondered if you are at risk for any of these conditions?

4. Finding out can bring peace of mind... “I was floored when I read my Navigenics results which found that my highest elevated risk condition (96-98%) was colon cancer - I have just been diagnosed with colon cancer. Had I known my genetic risk years ago, I may have been more proactive and caught it even earlier. The cost is a small price to pay to prolong your life, especially if you have young kids or a family to provide for. “ -Sempra finance employee, Female, 51

5. Finding out can bring peace of mind... “There’s a condition that I have 16 times the risk of developing as compared to the general population: macular degeneration. When added to the fact this is the reason that my grandmother is currently going blind, I’m suddenly a very motivated participant in my own health. While it’s a scary risk number, I’m now positioned to have an impact on it, and I’m incredibly happy that I know about it.” -Microsoft program manager, Male, 30

6. Finding out can bring peace of mind... “For years, I experienced stomach problems that never went away. My sister encouraged me to get a Navigenics genetic test and my results showed I was at high risk of celiac disease. My doctor recommended I cut out gluten from my diet, and in the three weeks since I changed my eating habits, I’ve lost eight pounds and my stomach problems have disappeared.” -Urgent care employee, Female, 23

7. Finding out can bring peace of mind... “My analysis was mostly reassuring, but showed two areas of increased risk. One was celiac disease, which was a surprise. I followed up the Navigenics report with a serologic test and an upper endoscopy, which were positive for moderately severe celiac disease. It is amazing to me, at the age of 52 years, and being a physician, that my diagnosis and treatment was possible only because of your DNA test.” -Head of oncology company, Male, 52

8. The Navi Experience • Your Storage at Fort “Navi” Your DNA 04677 04675 04678 04676 04679 Fort Navigenics You Your key “Navi” key

9. We Plug Your InformationInto a Database Insight Engine + Your DNA Database

10. Help From Your Doctorand a Genetic Health Coach Your conditions with a high risk: Actions youcan take: 43% Diabetes • Early screening • Early treatment • Lifestyle change • Right medicationsfor you Breast Cancer 26% Alzheimer’s 12% Your MD Your GeneticCounselor

11. “Navi” Subscription Service • Alerts & updatesabout you • Clinical trialspertinent to you • Additional thingsof interest Your DNA • ThinkingAbout You • 24/7 Insight Engine Your Risks MedicalInformation ConsumerKnowledge

12. The Value of What We Deliver = + The bestyou can be You

13. Complexity of Business… Genetics Science Predictive Science Regulation Consumer Engagement Physician Partnering Sales Channel Access …Is a Barrier to Entry

14. Employer Clients Unprecedented response rates averaging 27%

15. Widespread consumer interest Said they would have a genetic test for at least one disease condition Stated they would make health care decisions based upon genetic results Support nationwide genetic study

16. Physician & Academic Partners

17. Clinical Integration… Demonstrated Methods to Engage MDs and Integrate Into Clinical Practice Reduce the complexity of preventive genomics into focused educational programs Only company to… Integrate genetic counseling in service delivery Provide personalized tools to drive lifestyle changes based on genomics

18. 28 health conditions 24/7 access to our Genetic Counselors Updates for one year DNA storage Pharmacogenomics will be introduced in early 2010 Navigenics services Health Compass

19. Online summary genetic risk report Available within 2-4 weeks

20. Questions?