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To view the WHO classification of B cell neoplasms , select each category. Precursor B cell neoplasms. Mature B cell neoplasms. Hodgkin lymphoma. Note that you are not expected to memorize the WHO Classification system. It is presented to illustrate the diversity of B cell malignancies.
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To view the WHO classification of B cell neoplasms, select each category. Precursor B cell neoplasms Mature B cell neoplasms Hodgkin lymphoma Note that you are not expected to memorize the WHO Classification system. It is presented to illustrate the diversity of B cell malignancies.
Precursor B Cell Neoplasmsa • B-lymphoblastic leukemia/lymphoma not otherwise specified (B-ALL NOS) • B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities (B-ALL) a For clarity, some rare or provisional classifications have been omitted.
Mature B Cell Neoplasmsa • Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) • Diffuse large B cell lymphoma (DLBCL) • Primary mediastinal large B cell lymphoma • B cell prolymphocytic leukemia (B-PLL) • Primary effusion lymphoma • Lymphoplasmacytic lymphoma • Plasma cell myeloma (MM) • Waldenströmmacroglobulinemia (WM) • Solitary plasmacytoma of bone • Splenic marginal zone lymphoma • Extraosseousplasmacytoma • Hairy cell leukemia (HCL) • Anaplastic lymphoma kinase positive or negative large B cell lymphoma • Extranodal MALT lymphoma • Nodal marginal zone lymphoma • Plasmablastic lymphoma • Follicular lymphoma (FL) • Burkitt lymphoma (BL) • Primary cutaneous follicle center lymphoma • Heavy chain disease (HCD) • Mantle cell lymphoma (MCL) a For clarity, some rare or provisional classifications have been omitted.
Hodgkin Lymphomaa • Nodular lymphocyte-predominant Hodgkin lymphoma • Classical Hodgkin lymphoma • nodular sclerosis classical Hodgkin lymphoma • lymphocyte-rich classical Hodgkin lymphoma • mixed cellularity classical Hodgkin lymphoma • lymphocyte-depleted classical Hodgkin lymphoma a For clarity, some rare or provisional classifications have been omitted.
Select the B cell malignancies that may arise at each stage of B cell development. Centroblast <--------> Antigen-experienced mature B cell <--------> Plasmablast<-------->