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ERINHA: Framework for the biological high containment research infrastructure

ERINHA: Framework for the biological high containment research infrastructure. STOA – AVIESAN Workshop June 19th 2012, European Parliament, Brussels. Time table: Inclusion in the ESFRI roadmap in December 2008. A three steps project: Preparatory phase: 36 months, funded by EU.

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ERINHA: Framework for the biological high containment research infrastructure

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  1. ERINHA: Framework for the biological high containment research infrastructure STOA – AVIESAN Workshop June 19th 2012, European Parliament, Brussels

  2. Time table: • Inclusion in the ESFRI roadmap in December 2008. • A three steps project: • Preparatory phase: 36 months, funded by EU. • Construction and validation phase: 1-3 years, national funds. • Operation phase: at least 20 years, national funds. • Submission of the ERINHA proposal to Call 6: FP7- INFRASTRUCTURES-2010-1 for preparatory phase funding; December 2009. • Signature of the grant agreement; November 2010. • kick off meeting; November 2010.

  3. Global objective: To strengthen the EU capacities in the fields of diagnosis and study of highly pathogenic infectious micro-organisms

  4. Facing a grand challenge related to: • Emergence et re-emergence of highly pathogenic microorganisms (Nipah, H5N1, CCHF, BT…) • Occurrence of bioterrorist attack using risk group 4 pathogens

  5. Activities to be conducted: • Diagnosis • Research • To develop diagnosis tools, therapeutic and prophylactic means • Ranking from academic to finalized • Including animal experimentations

  6. Need for access to BSL-4 containment facility where the following services must be provided: • Biosafety and biosecurity • Training • Experimentation • Scientific support • Management of collection • Access to biological resources

  7. Present situation (1) Running BSL-4 laboratories in EU SMI BNI HPA PUM NCE Inserm INMI

  8. Present situation (2) • Restricted capacities in EU • Restricted number of experts in this field and all focused on virology • Restricted/No access for some EU scientist • Willingness of some country to build without expertise • Evolution of the regulation and creation of new standards • No coordination despite existence of networking activities

  9. Specific challenges • Building of BSL4 area is very costly and needs very specific expertise • Maintenance is also costly and can not be neglected to • ensure proper protection of workers and environment

  10. SMI BNI HPA PUM NCE Inserm INMI The ERINHA project proposes the creation of a distributed Pan European BSL-4 laboratory • Each National laboratory: • Brings part of its capacities to built ERINHA • Proposes access capacities • Share common procedures and practices • Share reagents

  11. Impact foreseen: • Improve response to health threats • Efficient use of resources • Access to BSL-4 facilities • Boost the European competitiveness • Access to research funds • Scientific Advancement

  12. Organization of work: • WP1: Management issues, Financial aspects and consortium agreement • WP2: Strategy and commitments • WP3: Governing structure and legal status • WP4: Technical work: Design considerations and estimating construction costs for new BSL4 areas • WP5: Definition, harmonization, standardization and dissemination of best practices in the management of biosafety and biosecurity issues in BSL4 laboratories and for associated biological resources centers • WP6: Access to BSL4 infrastructure for academic research, industrial research, and diagnosis activities • WP7 Research and diagnosis pilot activities

  13. Partners and associated partners: (20 partners, 15 countries, 13 associated partners)

  14. Thank you for your attention

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