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Diabetes

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Diabetes

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  1. Insulinoterapia Carrera de Enfermería Farmacología 17 de mayo 2010 Terapia Farmacológica en Diabetes Mellitus EU-Lic. Rene Castillo Flores Unidad de Fisiología y Farmacología Universidad Santo Tomás Sede Temuco - Chile

  2. Historia • 1921, Los fisiólogos canadienses Frederick G. Banting y Charles H. Best extrajeron por primera vez la insulina del tejido pancreático de los perros.

  3. Historia • 1922, administraron 15 ml de insulina exógena a un paciente diabético Leonard Thompson y su glicemia disminuyó de 440 a 320 mg/dL. • 1923 Premio Nóbel de Medicina descubrimiento de la insulina, MacLeod y Banting.

  4. Década 50 Insulina lenta Década 40 Protamina Neutra Hagedorn (NPH) Década 30 Insulina Protamina Zinc (PZI), Historia

  5. Historia 1996 FDA aprobó el primer análogo de insulina la Lispro Década 80 Análogos de insulina (ADN recombinante) Década 60-70 Insulinas purificadas.

  6. PANCREAS Acinos pancreáticos Células δ 5-10% (somatostatina) Célula α 20% (glucagon) Célula β (insulina) 70% Islotes de Langerhans

  7. Proinsulina

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