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Ligand-Gated Ion Channel: Structure and Activation States

Ligand-Gated Ion Channel: Structure and Activation States. Ligand-Gated Ion Channel: Structure and Activation States.

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Ligand-Gated Ion Channel: Structure and Activation States

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  1. Ligand-Gated Ion Channel: Structure and Activation States

  2. Ligand-Gated Ion Channel: Structure and Activation States • The intrinsic ion channel in this superfamily of receptors undergoes a conformational change following the binding of an extracellular ligand to its binding site, which allows for the opening of the channel pore. • The pore is formed by a pentameric arrangement of subunits, which are in turn composed of a large extracellular domain (which contains the ligand binding site) and four transmembrane domains.

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